Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 14/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 9/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 8/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 8/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 7/20 | 0.59 |
| ▸ | CYP2E1 | P05181 | 7/20 | 0.59 |
| ▸ | CYP2B6 | P20813 | 6/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.46 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.43 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10130586 | 0.86 | CYP2A6 (0.64) | CYP2A6CYP2C19CYP2C9CYP3A4CYP2D6 | |
| SCHEMBL13699162 | 0.85 | RORC (0.44) | CYP2A6CYP2C19CYP2C9CYP3A4CYP2D6 | |
| SCHEMBL10162003 | 0.81 | CYP2A6 (0.70) | CYP2A6CYP2C19CYP2C9CYP3A4CYP2D6 | |
| SCHEMBL13699263 | 0.79 | CYP2D6 (0.39) | CYP2A6CYP2C19CYP2C9CYP3A4CYP2D6 | |
| SCHEMBL13514034 | 0.77 | SLC5A2 (0.37) | CYP2A6CYP2C19CYP2C9CYP3A4CYP2D6 | |
| SCHEMBL13699203 | 0.75 | KDM4E (0.53) | CYP1A2HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL13035339 | 0.74 | CYP2A6 (0.70) | CYP2A6CYP2C19CYP2C9CYP3A4CYP2D6 | |
| SCHEMBL3610698 | 0.74 | CYP2A6 (1.00) | CYP2A6CYP2C19CYP2C9CYP3A4CYP2D6 | |
| SCHEMBL3611935 | 0.74 | CYP2A6 (1.00) | CYP2A6CYP2C19CYP2C9CYP3A4CYP2D6 | |
| SCHEMBL13003924 | 0.74 | MKNK1 (0.56) | CYP2A6CYP2C19CYP2C9CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7589067-B2 | 6, 11-bridged tricyclic macrolides | ENANTA PHARMACEUTICALS, INC. (US) | 2009-09-15 | — | — | US | disclosed |
| US-20070082853-A1 | 6, 11-bridged tricyclic macrolides | ENANTA PHARMACEUTICAL, INC. | 2007-04-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070082853-A1 | 6, 11-bridged tricyclic macrolides | CYP2B6, CYP2D6, ABCB11 | CYP2A6 4/4885CYP2C19 7/4885CYP2C9 10/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.