SCHEMBL13699467

SCHEMBL13699467

N#Cc1cc(CCO)cc(-n2nc3ccc(Cl)cc3n2)c1O

nearest known ligand 0.44

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 2/20 0.42
ALDH1A1 P00352 1/20 0.42
POLB P06746 1/20 0.42
HPGD P15428 1/20 0.42
ALOX15 P16050 1/20 0.42
MAPK1 P28482 1/20 0.42
HSD17B10 Q99714 1/20 0.42
NPC1 O15118 2/20 0.34
RAB9A P51151 2/20 0.34
RXFP1 Q9HBX9 1/20 0.32
PSMB8 P28062 1/20 0.32
MAPT P10636 1/20 0.32
ATM Q13315 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13699454 0.88 KDM4E (0.40) KDM4EALDH1A1POLBHPGDALOX15
SCHEMBL13700488 0.87 KDM4E (0.54) KDM4EALDH1A1POLBHPGDALOX15
SCHEMBL13700495 0.85 ALDH1A1 (0.43) KDM4EALDH1A1POLBHPGDALOX15
SCHEMBL13700496 0.83 ALDH1A1 (0.40) KDM4EALDH1A1POLBHPGDALOX15
SCHEMBL13699510 0.83 KDM4E (0.40) KDM4EALDH1A1POLBHPGDALOX15
SCHEMBL13699457 0.82 KDM4E (0.39) KDM4EALDH1A1POLBHPGDALOX15
SCHEMBL13700492 0.82 MEN1 (0.47) KDM4EALDH1A1POLBHPGDALOX15
SCHEMBL13700429 0.82 NPC1 (0.42) KDM4EALDH1A1POLBHPGDALOX15
SCHEMBL16690421 0.82 NPC1 (0.36) KDM4EALDH1A1POLBHPGDALOX15
SCHEMBL75316 0.82 NPC1 (0.36) KDM4EALDH1A1POLBHPGDALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2103445-B1 Heat resistance improver and reversible thermosensitive recording medium RICOH CO LTD (JP) 2015-05-06 EP disclosed
US-8324399-B2 Heat resistance improver and reversible thermosensitive recording medium RICOH COMPANY, LTD. (JP) 2012-12-04 US disclosed
US-20090239747-A1 HEAT RESISTANCE IMPROVER AND REVERSIBLE THERMOSENSITIVE RECORDING MEDIUM RICOH COMPANY, LTD. (JP) 2009-09-24 US disclosed
EP-2103445-A1 Heat resistance improver and reversible thermosensitive recording medium Ricoh Company, Ltd. (JP) 2009-09-23 EP disclosed