Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | HPGD | P15428 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | NQO1 | P15559 | 1/20 | 0.42 |
| ▸ | AHR | P35869 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 3/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1852815 | 0.87 | KDM4E (0.67) | KDM4EHSD17B10ALDH1A1HPGDMAPT | |
| SCHEMBL18412928 | 0.85 | MAPT (0.49) | KDM4EHSD17B10ALDH1A1HPGDMAPT | |
| SCHEMBL4257410 | 0.80 | KDM4E (0.77) | KDM4EHSD17B10ALDH1A1HPGDMAPT | |
| SCHEMBL13699685 | 0.80 | KDM4E (0.54) | KDM4EHSD17B10ALDH1A1HPGDMAPT | |
| SCHEMBL24845781 | 0.80 | KDM4E (0.50) | KDM4EHSD17B10ALDH1A1HPGDMAPT | |
| SCHEMBL13699689 | 0.80 | KDM4E (0.50) | KDM4EHSD17B10ALDH1A1HPGDMAPT | |
| SCHEMBL13699680 | 0.79 | KDM4E (0.57) | KDM4EHSD17B10ALDH1A1HPGDMAPT | |
| SCHEMBL20535965 | 0.78 | KDM4E (0.60) | KDM4EHSD17B10ALDH1A1HPGDMAPT | |
| SCHEMBL18394631 | 0.78 | KDM4E (0.67) | KDM4EHSD17B10ALDH1A1HPGDMAPT | |
| SCHEMBL20535434 | 0.78 | KDM4E (0.51) | KDM4EHSD17B10ALDH1A1HPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4615578-A1 | CYCLIC PYRIDINE DERIVATIVES AS CGAS INHIBITORS | Boehringer Ingelheim International GmbH (DE) | 2025-09-17 | — | — | EP | disclosed |
| US-20240189315-A1 | Cyclic Pyridine Derivatives as cGAS Inhibitors | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2024-06-13 | — | — | US | disclosed |
| WO-2024099908-A1 | CYCLIC PYRIDINE DERIVATIVES AS CGAS INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2024-05-16 | — | — | WO | disclosed |
| US-20230000878-A1 | PYRIDINE DERIVATIVES WITH N-LINKED CYCLIC SUBSTITUENTS AS cGAS INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2023-01-05 | — | — | US | disclosed |
| US-20090239860-A1 | NOVEL BENZOFURAN DERIVATIVE, MEDICINAL COMPOSITION CONTAINING THE SAME, AND USES OF THESE | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2009-09-24 | — | — | US | disclosed |
| US-20090239860-A1 | NOVEL BENZOFURAN DERIVATIVE, MEDICINAL COMPOSITION CONTAINING THE SAME, AND USES OF THESE | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2009-09-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090239860-A1 | NOVEL BENZOFURAN DERIVATIVE, MEDICINAL COMPOSITION CONTAINING THE SAME, AND USES OF THESE | ADORA2A, ADORA2B, HTR1F | KDM4E 4227/4885HSD17B10 1250/4885ALDH1A1 559/4885 |
| US-20240189315-A1 | Cyclic Pyridine Derivatives as cGAS Inhibitors | CGAS, STING1, IRF3 | KDM4E 1598/4885HSD17B10 1693/4885ALDH1A1 1257/4885 |
| US-20230000878-A1 | PYRIDINE DERIVATIVES WITH N-LINKED CYCLIC SUBSTITUENTS AS cGAS INHIBITORS | CGAS, GLS2, GMPS | KDM4E 3126/4885HSD17B10 1489/4885ALDH1A1 1112/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.