Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 5/20 | 0.38 |
| ▸ | CNR1 | P21554 | 2/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | FOXO1 | Q12778 | 1/20 | 0.35 |
| ▸ | IL1B | P01584 | 9/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 9/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13699782 | 0.89 | P2RX7 (0.41) | CNR2CNR1IL1BP2RX7 | |
| SCHEMBL1019651 | 0.89 | CNR2 (0.39) | CNR2CNR1PDE10AFOXO1IL1B | |
| SCHEMBL13672996 | 0.88 | P2RX7 (0.38) | CNR2IL1BP2RX7 | |
| SCHEMBL1020417 | 0.88 | IL1B (0.44) | IL1BP2RX7 | |
| SCHEMBL1019261 | 0.88 | CNR2 (0.38) | CNR2CNR1PDE10AFOXO1IL1B | |
| SCHEMBL13672991 | 0.88 | CNR2 (0.35) | CNR2IL1BP2RX7ALDH1A1MEN1 | |
| SCHEMBL12955184 | 0.84 | P2RX7 (0.44) | CNR2IL1BP2RX7 | |
| SCHEMBL13672992 | 0.82 | CNR2 (0.38) | CNR2CNR1IL1BP2RX7ALDH1A1 | |
| SCHEMBL1020147 | 0.82 | KDM4E (0.36) | CNR2CNR1FOXO1IL1BP2RX7 | |
| SCHEMBL1021343 | 0.82 | P2RX7 (0.39) | CNR2IL1BP2RX7KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2105164-A1 | Novel P2X7R antagonists and their use | Affectis Pharmaceuticals AG (DE) | 2009-09-30 | — | — | EP | disclosed |