Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.62 |
| ▸ | MAPT | P10636 | 2/20 | 0.62 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.61 |
| ▸ | SMPD1 | P17405 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | NPC1 | O15118 | 3/20 | 0.57 |
| ▸ | RAB9A | P51151 | 3/20 | 0.57 |
| ▸ | KAT6A | Q92794 | 2/20 | 0.57 |
| ▸ | TSHR | P16473 | 2/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | THRB | P10828 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13701712 | 0.93 | LMNA (0.65) | LMNAKMT2ASMN1; SMN2MAPTNR1H4 | |
| SCHEMBL12133228 | 0.88 | LMNA (0.82) | LMNAKMT2ASMN1; SMN2MAPTNR1H4 | |
| SCHEMBL13701726 | 0.84 | LMNA (0.58) | LMNAKMT2ASMN1; SMN2MAPTNR1H4 | |
| SCHEMBL11213011 | 0.84 | KMT2A (0.69) | LMNAKMT2ASMN1; SMN2MAPTNR1H4 | |
| SCHEMBL13702374 | 0.84 | KMT2A (0.69) | LMNAKMT2ASMN1; SMN2MAPTNR1H4 | |
| SCHEMBL19079018 | 0.82 | PLK1 (0.69) | LMNAKMT2ASMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL13702136 | 0.81 | KMT2A (0.66) | LMNAKMT2ASMN1; SMN2MAPTNR1H4 | |
| SCHEMBL13701708 | 0.81 | ESR1 (0.58) | LMNASMN1; SMN2ALDH1A1GAANPSR1 | |
| SCHEMBL13701702 | 0.81 | LMNA (0.55) | LMNAKMT2ASMPD1ALDH1A1TSHR | |
| SCHEMBL13701690 | 0.81 | SMPD1 (0.71) | LMNAKMT2ANR1H4SMPD1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090227588-A1 | Substituted pyrazole compounds useful as soluble epoxide hyrolase inhibitors | FLECK ROMAN WOLFGANG | 2009-09-10 | — | — | US | disclosed |
| US-20090227588-A1 | Substituted pyrazole compounds useful as soluble epoxide hyrolase inhibitors | FLECK ROMAN WOLFGANG | 2009-09-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090227588-A1 | Substituted pyrazole compounds useful as soluble epoxide hyrolase inhibitors | EPHX1, EPHX2, EPX | LMNA 1843/4885KMT2A 3792/4885SMN1; SMN2 4398/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.