Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 8/20 | 0.60 |
| ▸ | NPC1 | O15118 | 7/20 | 0.60 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.54 |
| ▸ | TP53 | P04637 | 2/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | F2 | P00734 | 1/20 | 0.53 |
| ▸ | TLR4 | O00206 | 1/20 | 0.53 |
| ▸ | TLR2 | O60603 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 3/20 | 0.52 |
| ▸ | TSHR | P16473 | 3/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | FLT3 | P36888 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14438266 | 0.82 | NPC1 (0.55) | RAB9ANPC1SIRT2SMN1; SMN2L3MBTL1 | |
| SCHEMBL2943454 | 0.81 | RAB9A (0.66) | RAB9ANPC1SIRT2SMN1; SMN2L3MBTL1 | |
| SCHEMBL8556579 | 0.81 | GRM5 (0.67) | RAB9ANPC1SIRT2SMN1; SMN2L3MBTL1 | |
| SCHEMBL16996704 | 0.81 | RAB9A (0.66) | RAB9ANPC1SIRT2SMN1; SMN2L3MBTL1 | |
| SCHEMBL13702329 | 0.81 | NPC1 (0.60) | RAB9ANPC1SIRT2SMN1; SMN2L3MBTL1 | |
| SCHEMBL10943062 | 0.81 | NPC1 (0.60) | RAB9ANPC1SIRT2SMN1; SMN2L3MBTL1 | |
| SCHEMBL13611929 | 0.80 | KAT6A (0.55) | SIRT2 | |
| SCHEMBL21249304 | 0.80 | LMNA (0.58) | RAB9ANPC1SMN1; SMN2KMT2AHTT | |
| SCHEMBL6327544 | 0.79 | NPC1 (0.55) | RAB9ANPC1SIRT2SMN1; SMN2L3MBTL1 | |
| SCHEMBL29366822 | 0.78 | RAB9A (0.89) | RAB9ANPC1SMN1; SMN2L3MBTL1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090227588-A1 | Substituted pyrazole compounds useful as soluble epoxide hyrolase inhibitors | FLECK ROMAN WOLFGANG | 2009-09-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090227588-A1 | Substituted pyrazole compounds useful as soluble epoxide hyrolase inhibitors | EPHX1, EPHX2, EPX | RAB9A 2708/4885NPC1 1477/4885SIRT2 2651/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.