Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK2 | Q15119 | 12/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.41 |
| ▸ | PTPRC | P08575 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13702054 | 0.95 | PDK2 (0.55) | PDK2TDP1ATML3MBTL1THRB | |
| SCHEMBL134286 | 0.95 | PDK2 (0.58) | PDK2TDP1ATML3MBTL1THRB | |
| SCHEMBL134285 | 0.95 | PDK2 (0.58) | PDK2TDP1ATML3MBTL1THRB | |
| SCHEMBL29114 | 0.95 | PDK2 (0.58) | PDK2TDP1ATML3MBTL1THRB | |
| SCHEMBL133477 | 0.93 | PDK2 (0.66) | PDK2TDP1ATML3MBTL1CNR2 | |
| SCHEMBL1552743 | 0.93 | PDK2 (0.66) | PDK2TDP1ATML3MBTL1CNR2 | |
| SCHEMBL12337045 | 0.93 | PDK2 (0.60) | PDK2TDP1ATML3MBTL1PTPRC | |
| SCHEMBL12200611 | 0.90 | PDK2 (0.54) | PDK2TDP1THRB | |
| SCHEMBL13423240 | 0.89 | PDK2 (0.50) | PDK2TDP1ATML3MBTL1 | |
| SCHEMBL22175362 | 0.89 | PDK2 (0.50) | PDK2TDP1ATML3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090234164-A1 | Oligomeric derivatives of spirobifluorene, their preparation and use | MERCK PATENT GMBH (DE) | 2009-09-17 | — | — | US | disclosed |
| US-20090234164-A1 | Oligomeric derivatives of spirobifluorene, their preparation and use | MERCK PATENT GMBH (DE) | 2009-09-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090234164-A1 | Oligomeric derivatives of spirobifluorene, their preparation and use | NR3C2, NR0B2, NR0B1 | PDK2 2805/4885TDP1 3976/4885ATM 2850/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.