Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 1/20 | 0.46 |
| ▸ | NCF1 | P14598 | 2/20 | 0.42 |
| ▸ | BACE1 | P56817 | 2/20 | 0.42 |
| ▸ | F12 | P00748 | 1/20 | 0.42 |
| ▸ | PLAU | P00749 | 1/20 | 0.42 |
| ▸ | NOS3 | P29474 | 1/20 | 0.42 |
| ▸ | NOS1 | P29475 | 1/20 | 0.42 |
| ▸ | NOS2 | P35228 | 1/20 | 0.42 |
| ▸ | DCPS | Q96C86 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.37 |
| ▸ | CCR4 | P51679 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12145214 | 0.81 | KDM4E (0.46) | HTR3ANCF1BACE1F12PLAU | |
| SCHEMBL31631613 | 0.81 | KDM4E (0.46) | HTR3ANCF1BACE1F12PLAU | |
| SCHEMBL24995419 | 0.78 | TSHR (0.38) | HSD17B10CYP1B1CYP1A2CCR4ALDH1A1 | |
| SCHEMBL10220781 | 0.78 | CYP2A6 (0.44) | HSD17B10KDM4ECYP1B1CYP1A2CCR4 | |
| SCHEMBL15427884 | 0.77 | CCR4 (0.36) | HSD17B10CYP1B1CYP1A2CCR4ALDH1A1 | |
| SCHEMBL24174415 | 0.75 | SYK (0.50) | NOS3NOS1NOS2DCPSHSD17B10 | |
| SCHEMBL24174649 | 0.74 | ATM (0.36) | HSD17B10CYP1B1CYP1A2CCR4ALDH1A1 | |
| SCHEMBL25465465 | 0.74 | HMGCR (0.38) | HSD17B10KDM4ECYP1B1CYP1A2CCR4 | |
| SCHEMBL5529985 | 0.74 | ADORA2A (0.47) | HTR3AKDM4ECCR4ALDH1A1LMNA | |
| SCHEMBL5034624 | 0.74 | NCF1 (0.52) | HTR3ANCF1BACE1F12PLAU |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022002118-A1 | FUSED-RING HETEROCYCLE DERIVATIVE AND MEDICAL USE THEREOF | 四川海思科制药有限公司 | 2022-01-06 | — | — | WO | disclosed |
| US-20170309832-A1 | METAL COMPLEXES | MERCK PATENT GMBH (DE) | 2017-10-26 | — | — | US | disclosed |
| US-20170309832-A1 | METAL COMPLEXES | MERCK PATENT GMBH (DE) | 2017-10-26 | — | — | US | disclosed |
| US-9673402-B2 | Platinum metal complexes with divalent groups bridging two ligands | MERCK PATENT GMBH (DE) | 2017-06-06 | — | — | US | disclosed |
| US-9673402-B2 | Platinum metal complexes with divalent groups bridging two ligands | MERCK PATENT GMBH (DE) | 2017-06-06 | — | — | US | disclosed |
| US-9273080-B2 | Metal complexes | MEREK PATENT GMBH (DE) | 2016-03-01 | — | — | US | disclosed |
| US-9273080-B2 | Metal complexes | MEREK PATENT GMBH (DE) | 2016-03-01 | — | — | US | disclosed |
| US-9169282-B2 | Metal complexes | MERCK PATENT GMBH (DE) | 2015-10-27 | — | — | US | disclosed |
| US-9169282-B2 | Metal complexes | MERCK PATENT GMBH (DE) | 2015-10-27 | — | — | US | disclosed |
| US-9169282-B2 | Metal complexes | MERCK PATENT GMBH (DE) | 2015-10-27 | — | — | US | disclosed |
| EP-2726490-B1 | METAL COMPLEXES | MERCK PATENT GMBH (DE) | 2015-04-29 | — | — | EP | disclosed |
| US-20130082209-A1 | METAL COMPLEXES | MERCK PATENT GMBH (DE) | 2013-04-04 | — | — | US | disclosed |
| US-20130082209-A1 | METAL COMPLEXES | MERCK PATENT GMBH (DE) | 2013-04-04 | — | — | US | disclosed |
| WO-2013000531-A1 | METAL COMPLEXES | MERCK PATENT GMBH (DE) | 2013-01-03 | — | — | WO | disclosed |
| WO-2011157339-A1 | METAL COMPLEXES | MERCK PATENT GMBH (DE) | 2011-12-22 | — | — | WO | disclosed |
| US-20110284799-A1 | METAL COMPLEXES | MERCK PATENT GMBH (DE) | 2011-11-24 | — | — | US | disclosed |
| US-20110284799-A1 | METAL COMPLEXES | MERCK PATENT GMBH (DE) | 2011-11-24 | — | — | US | disclosed |
| US-20110284799-A1 | METAL COMPLEXES | MERCK PATENT GMBH (DE) | 2011-11-24 | — | — | US | disclosed |
| WO-2010086089-A1 | METAL COMPLEXES | MERCK PATENT GMBH (DE) | 2010-08-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110284799-A1 | METAL COMPLEXES | SOD1, AP1M1, AP3M1 | HTR3A 4552/4885NCF1 1129/4885BACE1 2807/4885 |
| US-20130082209-A1 | METAL COMPLEXES | MCOLN2, MCOLN1, AP1M1 | HTR3A 4398/4885NCF1 458/4885BACE1 1595/4885 |
| US-20170309832-A1 | METAL COMPLEXES | SOD1, AP1M1, AP3M1 | HTR3A 4552/4885NCF1 1129/4885BACE1 2807/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.