Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 3/20 | 0.35 |
| ▸ | USP19 | O94966 | 3/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 9/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 9/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4287333 | 0.99 | CHEK2 (0.35) | CHEK2USP19HCRTR1HCRTR2ROCK2 | |
| Hydrochloric Acid SCHEMBL4287152 | 0.94 | MEN1 (0.37) | USP19HCRTR1HCRTR2ROCK2KDM4E | |
| SCHEMBL4290797 | 0.93 | HCRTR1 (0.36) | USP19HCRTR1HCRTR2KDM4EALDH1A1 | |
| SCHEMBL4285368 | 0.93 | USP19 (0.35) | USP19HCRTR1HCRTR2ROCK2KDM4E | |
| SCHEMBL4287688 | 0.92 | HCRTR1 (0.37) | USP19HCRTR1HCRTR2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL4291173 | 0.92 | CACNA1F (0.34) | USP19HCRTR1HCRTR2ROCK2ALDH1A1 | |
| SCHEMBL4284435 | 0.91 | HCRTR1 (0.40) | USP19HCRTR1HCRTR2 | |
| Hydrochloric Acid SCHEMBL4294065 | 0.91 | HCRTR1 (0.37) | USP19HCRTR1HCRTR2ALDH1A1 | |
| SCHEMBL4281297 | 0.91 | FKBP1A (0.39) | CHEK2USP19HCRTR1HCRTR2 | |
| Hydrochloric Acid SCHEMBL4292754 | 0.91 | HCRTR1 (0.36) | USP19HCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090227560-A1 | Substituted imidazole compound and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-09-10 | — | — | US | disclosed |
| US-20090227560-A1 | Substituted imidazole compound and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-09-10 | — | — | US | disclosed |
| US-20090156612-A1 | Substituted imidazole compound and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-06-18 | — | — | US | disclosed |
| US-20090156612-A1 | Substituted imidazole compound and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-06-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090156612-A1 | Substituted imidazole compound and use thereof | REN, ACE, AGT | CHEK2 3289/4885USP19 1993/4885HCRTR1 3147/4885 |
| US-20090227560-A1 | Substituted imidazole compound and use thereof | REN, ACE, AGT | CHEK2 3289/4885USP19 1993/4885HCRTR1 3147/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.