Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | GALR2 | O43603 | 1/20 | 0.43 |
| ▸ | MITF | O75030 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | XBP1 | P17861 | 1/20 | 0.43 |
| ▸ | CCR6 | P51684 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2656516 | 0.86 | POLB (0.50) | SMN1; SMN2ALDH1A1KMT2AMEN1POLB | |
| SCHEMBL9793680 | 0.86 | POLB (0.50) | SMN1; SMN2ALDH1A1KMT2AMEN1POLB | |
| SCHEMBL6168992 | 0.86 | SMN1; SMN2 (0.62) | SMN1; SMN2ALDH1A1KMT2AMEN1LMNA | |
| SCHEMBL20395326 | 0.85 | HSD17B10 (0.51) | SMN1; SMN2ALDH1A1KMT2AMEN1POLB | |
| SCHEMBL8421994 | 0.84 | ALDH1A1 (0.55) | SMN1; SMN2ALDH1A1KMT2AMEN1LMNA | |
| SCHEMBL8953331 | 0.82 | SMN1; SMN2 (0.47) | SMN1; SMN2ALDH1A1KMT2AMEN1LMNA | |
| SCHEMBL5369486 | 0.82 | KMT2A (0.50) | SMN1; SMN2ALDH1A1KMT2AMEN1LMNA | |
| SCHEMBL16957915 | 0.81 | ALDH1A1 (0.50) | SMN1; SMN2ALDH1A1KMT2AMEN1LMNA | |
| SCHEMBL7414257 | 0.81 | SMN1; SMN2 (0.46) | SMN1; SMN2ALDH1A1KMT2AMEN1LMNA | |
| SCHEMBL5988015 | 0.81 | SMN1; SMN2 (0.49) | SMN1; SMN2ALDH1A1KMT2AMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2098513-A1 | TRICYCLIC COMPOUND AND PHARMACEUTICAL USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2009-09-09 | — | — | EP | disclosed |