Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.61 |
| ▸ | LMNA | P02545 | 3/20 | 0.61 |
| ▸ | HPGD | P15428 | 2/20 | 0.61 |
| ▸ | POLB | P06746 | 2/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.61 |
| ▸ | GALR2 | O43603 | 1/20 | 0.61 |
| ▸ | MITF | O75030 | 1/20 | 0.61 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.61 |
| ▸ | XBP1 | P17861 | 1/20 | 0.61 |
| ▸ | CCR6 | P51684 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13705663 | 0.86 | SMN1; SMN2 (0.49) | SMN1; SMN2ALDH1A1LMNAHPGDPOLB | |
| SCHEMBL9793680 | 0.82 | POLB (0.50) | SMN1; SMN2ALDH1A1HPGDPOLBNPSR1 | |
| SCHEMBL2656516 | 0.82 | POLB (0.50) | SMN1; SMN2ALDH1A1HPGDPOLBNPSR1 | |
| SCHEMBL20395326 | 0.81 | HSD17B10 (0.51) | SMN1; SMN2ALDH1A1HPGDPOLBNPSR1 | |
| SCHEMBL6656676 | 0.80 | MEN1 (0.68) | SMN1; SMN2ALDH1A1LMNAHPGDPOLB | |
| SCHEMBL18285205 | 0.80 | TSHR (0.56) | SMN1; SMN2ALDH1A1LMNAHPGDPOLB | |
| SCHEMBL7312805 | 0.80 | LMNA (0.71) | SMN1; SMN2ALDH1A1LMNAHPGDNPSR1 | |
| SCHEMBL16407064 | 0.79 | HSD17B10 (0.61) | SMN1; SMN2ALDH1A1LMNAHPGDPOLB | |
| SCHEMBL3789796 | 0.79 | ALDH1A1 (0.64) | SMN1; SMN2ALDH1A1HPGDPOLBKMT2A | |
| SCHEMBL27507150 | 0.79 | ALDH1A1 (0.61) | SMN1; SMN2ALDH1A1LMNAHPGDPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0882718-B1 | BENZIMIDAZOLE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO (JP) | 2005-08-31 | — | — | EP | disclosed |
| US-6352985-B1 | CARDIOVASCULAR DISORDERS OR GASTROINTESTINAL DISORDERS, DIABETES (TYPE II DIABETES), DIABETIC COMPLICATIONS METHOD FOR LOWERING THE BLOOD SUGAR LEVEL OF A PATIENT, | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-03-05 | — | — | US | disclosed |
| US-6166219-A | Benzimidazole derivatives | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-12-26 | — | — | US | disclosed |
| EP-0882718-A1 | BENZIMIDAZOLE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-12-09 | — | — | EP | disclosed |