Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 11/20 | 1.00 |
| ▸ | BRD4 | O60885 | 3/20 | 0.53 |
| ▸ | PARP1 | P09874 | 3/20 | 0.53 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.52 |
| ▸ | RORA | P35398 | 2/20 | 0.52 |
| ▸ | RORC | P51449 | 2/20 | 0.52 |
| ▸ | RORB | Q92753 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | TNKS | O95271 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | GPR3 | P46089 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11463987 | 0.75 | PGR (0.59) | PGRNR1H3KDM4EMEN1ALDH1A1 | |
| SCHEMBL27936896 | 0.74 | KIF11 (0.68) | PGRPARP1KDM4EMEN1TNKS | |
| SCHEMBL2150990 | 0.73 | PARP1 (0.64) | PGRBRD4PARP1KDM4EMEN1 | |
| SCHEMBL15935048 | 0.73 | PARP1 (0.64) | PGRBRD4PARP1KDM4EMEN1 | |
| SCHEMBL11554945 | 0.71 | MAP2 (0.60) | PGRKDM4EMEN1ALDH1A1KMT2A | |
| SCHEMBL11555822 | 0.70 | PGR (0.54) | PGRNR1H3RORARORCRORB | |
| SCHEMBL11554157 | 0.70 | PGR (0.53) | PGRKDM4EMEN1ALDH1A1CYP1A2 | |
| SCHEMBL11550795 | 0.70 | MAP2 (0.65) | PGRKDM4EMEN1ALDH1A1KMT2A | |
| SCHEMBL30466766 | 0.69 | PARP1 (0.64) | PGRBRD4PARP1KDM4EMEN1 | |
| SCHEMBL7852218 | 0.69 | PARP1 (0.64) | PGRBRD4PARP1KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009107389-A1 | TRICYCLIC COMPOUND | 国立大学法人東京大学 (JP) | 2009-09-03 | — | — | WO | disclosed |