Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.32 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5368019 | 0.95 | PDE10A (0.41) | ALDH1A1ALOX15TSHRPDE10AKDM4E | |
| SCHEMBL15247491 | 0.87 | PDE10A (0.38) | PDE10A | |
| SCHEMBL1318906 | 0.86 | RAB9A (0.41) | ALDH1A1ALOX15TSHRKDM4ENFKB1 | |
| SCHEMBL11138006 | 0.85 | ALDH1A1 (0.47) | ALDH1A1ALOX15TSHRKDM4ENFKB1 | |
| SCHEMBL5381295 | 0.85 | SOAT1 (0.37) | KDM4ENFKB1LMNAHSD17B10NPC1 | |
| SCHEMBL11393908 | 0.83 | NR5A1 (0.40) | ALDH1A1TSHRLMNATP53GAA | |
| SCHEMBL17563551 | 0.83 | NR5A1 (0.40) | ALDH1A1TSHRLMNATP53GAA | |
| SCHEMBL11652521 | 0.83 | NR5A1 (0.40) | ALDH1A1TSHRLMNATP53GAA | |
| SCHEMBL6051629 | 0.82 | RAB9A (0.41) | KDM4ENFKB1LMNAHSD17B10NPC1 | |
| SCHEMBL632364 | 0.82 | PDE10A (0.39) | ALDH1A1TSHRPDE10ALMNAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8530652-B2 | Pyrrolopyrazoles, potent kinase inhibitors | AGOURON PHARMACEUTICALS, INC. (US) | 2013-09-10 | — | — | US | disclosed |
| EP-2123635-B1 | METHOD FOR PRODUCTION OF LAUROLACTAM | UNIV NAGOYA NAT UNIV CORP (JP) | 2013-06-05 | — | — | EP | disclosed |
| US-20120264751-A1 | PYRROLOPYRAZOLES, POTENT KINASE INHIBITORS | AGOURON PHARMACEUTICALS, INC. | 2012-10-18 | — | — | US | disclosed |
| US-8163899-B2 | Process for producing laurolactam | NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY (JP) | 2012-04-24 | — | — | US | disclosed |
| US-8067591-B2 | Pyrrolopyrazole, potent kinase inhibitors | AGOURON PHARMACEUTICALS, INC. (US) | 2011-11-29 | — | — | US | disclosed |
| EP-1838718-B1 | PYRROLOPYRAZOLES, POTENT KINASE INHIBITORS | PFIZER (US) | 2011-06-15 | — | — | EP | disclosed |
| US-20100324283-A1 | PROCESS FOR PRODUCING LAUROLACTAM | NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY (JP) | 2010-12-23 | — | — | US | disclosed |
| US-20100222342-A1 | PYRROLOPYRAZOLE, POTENT KINASE INHIBITORS | ZHANG JUNHU | 2010-09-02 | — | — | US | disclosed |
| EP-2123635-A1 | METHOD FOR PRODUCTION OF LAUROLACTAM | National University Corporation Nagoya University (JP) | 2009-11-25 | — | — | EP | disclosed |
| EP-0626950-B1 | TRIAZINE DERIVATES WITH UV-FILTER PROPERTIES | MERCK PATENT GMBH (DE) | 2001-10-24 | — | — | EP | disclosed |
| US-4942233-A | LIQUID CRYSTALS | MONTEDISON S.P.A. (IT) | 1990-07-17 | — | — | US | disclosed |
| US-4939243-A | Water-soluble copper complex disazo compounds containg a chloro triazinylamino group and a group of the vinylsulfone series as fiber-reactive groups and their dyestuffs | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-07-03 | — | — | US | disclosed |
| EP-0300753-A2 | Thermotropic DI-S-triazinic derivatives | Montedison S.p.A. (IT) | 1989-01-25 | — | — | EP | disclosed |
| EP-0084849-B1 | WATER SOLUBLE COPPER COMPLEXES OF DISAZO COMPOUNDS, PROCESS FOR THEIR PREPARATION AND THEIR USE AS DYESTUFFS | HOECHST AKTIENGESELLSCHAFT (DE) | 1986-05-14 | — | — | EP | disclosed |
| US-4402755-A | HYDROLYZED DICHLORO-S-TRIAZINE DERIVATIVE | KONISHIROKU PHOTO INDUSTRY CO., LTD. (JP) | 1983-09-06 | — | — | US | disclosed |
| EP-0084849-A2 | Water soluble copper complexes of disazo compounds, process for their preparation and their use as dyestuffs | HOECHST AKTIENGESELLSCHAFT (DE) | 1983-08-03 | — | — | EP | disclosed |
| US-4330469-A | Reactive dyes, processes for their manufacture and their use | CIBA-GEIGY CORPORATION (US) | 1982-05-18 | — | — | US | disclosed |
| EP-0001614-A1 | Water-soluble, fibre-reactive, green azo-phthalocyanine dyestuffs, their preparation and their application, as well as the phthalocyanine pyrazolone intermediates and their preparation | CASSELLA Aktiengesellschaft (DE) | 1979-05-02 | — | — | EP | disclosed |
| US-4054559-A | Reactive disazo monohalogenotriazine dyestuffs | NIPPON KAYAKU KABUSHIKI KAISHA (JA) | 1977-10-18 | — | — | US | disclosed |
| US-4007183-A | 2-ALKYL OR ALKOXY-4,6-DISALICYLOYL-HYDRAZINO-S-TRIAZINE | CIBA-GEIGY CORPORATION (US) | 1977-02-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120264751-A1 | PYRROLOPYRAZOLES, POTENT KINASE INHIBITORS | PAK4, PAK5, PAK3 | ALDH1A1 2941/4885ALOX15 4053/4885TSHR 4624/4885 |
| US-20100222342-A1 | PYRROLOPYRAZOLE, POTENT KINASE INHIBITORS | PAK4, PAK5, PAK3 | ALDH1A1 3130/4885ALOX15 3910/4885TSHR 4556/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.