Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.56 |
| ▸ | CASP1 | P29466 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | HTR1A | P08908 | 2/20 | 0.48 |
| ▸ | DRD2 | P14416 | 2/20 | 0.48 |
| ▸ | MAOA | P21397 | 2/20 | 0.44 |
| ▸ | MAOB | P27338 | 2/20 | 0.44 |
| ▸ | HTR2A | P28223 | 2/20 | 0.43 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.43 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.42 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL55137 | 0.87 | HTR1A (0.58) | ALDH1A1HPGDALOX15ALOX12CASP1 | |
| SCHEMBL647527 | 0.79 | ALDH1A1 (0.40) | ALDH1A1HPGDALOX15ALOX12CASP1 | |
| SCHEMBL2996327 | 0.78 | HTR2A (0.68) | ALDH1A1HPGDALOX15ALOX12CASP1 | |
| SCHEMBL27923108 | 0.78 | HTR2A (0.54) | ALDH1A1HPGDALOX15ALOX12CASP1 | |
| SCHEMBL24244161 | 0.76 | TDP1 (0.68) | ALDH1A1HPGDALOX15ALOX12CASP1 | |
| SCHEMBL3091432 | 0.76 | HTT (0.53) | ALDH1A1HPGDALOX15ALOX12CASP1 | |
| SCHEMBL8061521 | 0.76 | HTR2A (0.54) | ALDH1A1HPGDALOX15ALOX12CASP1 | |
| SCHEMBL11784607 | 0.76 | HTR2A (0.72) | MAOAMAOBHTR2ACYP2A6SMN1; SMN2 | |
| SCHEMBL698588 | 0.76 | TDP1 (0.54) | ALDH1A1HPGDALOX15ALOX12CASP1 | |
| SCHEMBL5541602 | 0.76 | HTR1A (0.48) | ALDH1A1HPGDALOX15ALOX12CASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582667-B2 | Dihydrospiro[dibenzo[a,d][7]annulene-5,4′-imidazol] compounds for the inhibition of beta-secretase | WYETH (US) | 2009-09-01 | — | — | US | disclosed |
| US-20070203116-A1 | Dihydrospiro[dibenzo[a,d][7]annulene-5,4'-imidazol] compounds for the inhibition of beta-secretase | WYETH (US) | 2007-08-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070203116-A1 | Dihydrospiro[dibenzo[a,d][7]annulene-5,4'-imidazol] compounds for the inhibition of beta-secretase | BACE1, BACE2, APP | ALDH1A1 472/4885HPGD 1534/4885ALOX15 902/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.