SCHEMBL647527

SCHEMBL647527

ICc1ccccc1CI

nearest known ligand 0.40

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.40
HPGD P15428 1/20 0.40
ALOX15 P16050 1/20 0.40
ALOX12 P18054 1/20 0.40
CASP1 P29466 1/20 0.40
HSD17B10 Q99714 1/20 0.40
HSPA5 P11021 1/20 0.38
TAAR1 Q96RJ0 6/20 0.38
IDO1 P14902 3/20 0.36
PNMT P11086 1/20 0.35
CYP1A1 P04798 1/20 0.33
CYP1A2 P05177 1/20 0.33
CYP1B1 Q16678 1/20 0.33
CYP2D6 P10635 1/20 0.33
TSHR P16473 1/20 0.33
HIF1A Q16665 1/20 0.33
APOBEC3G Q9HC16 1/20 0.33
DPP4 P27487 1/20 0.32
AKR1B1 P15121 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28200404 0.87 ALDH1A1 (0.33) ALDH1A1HPGDALOX15ALOX12CASP1
SCHEMBL15652973 0.85 ALDH1A1 (0.39) ALDH1A1HPGDALOX15ALOX12CASP1
SCHEMBL8611081 0.85 PNMT (0.50) TAAR1IDO1PNMTDPP4
SCHEMBL8346810 0.85 GABRA1 (0.46) ALDH1A1CYP2D6
SCHEMBL15653990 0.85 ALDH1A1 (0.41) ALDH1A1HPGDALOX15ALOX12CASP1
SCHEMBL14709942 0.85 APOBEC3G (0.48) ALDH1A1HPGDHSPA5TAAR1TSHR
SCHEMBL29712508 0.83 DPP4 (0.41) ALDH1A1HPGDALOX15ALOX12CASP1
SCHEMBL2290496 0.81
SCHEMBL284465 0.81
SCHEMBL8645715 0.81 ALDH1A1 (0.40) ALDH1A1HPGDALOX15ALOX12CASP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 244 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4016194-A CATALYTIC CARBONYLATION TEXACO INC. (US) 1977-04-05 US claimed
US-12616576-B2 Methods of modifying the porous surface of implants BIOMET MANUFACTURING, LLC (US) 2026-05-05 US disclosed
US-12605488-B2 Surface treatment methods for cementless implantable medical devices DURAHIP, LLC (US) 2026-04-21 US disclosed
CN-114650979-B Compound, mixture, curable resin composition, cured product thereof, and method for producing compound 日本化药株式会社 2024-09-17 CN disclosed
US-20240207482-A1 SURFACE TREATMENT METHODS FOR CEMENTLESS IMPLANTABLE MEDICAL DEVICES DURAHIP, LLC 2024-06-27 US disclosed
CN-118053799-A Method for manufacturing semiconductor device 株式会社力森诺科 2024-05-17 CN disclosed
CN-115382402-B Preparation method of composite membrane material 天津工业大学 2024-02-02 CN disclosed
CN-117157733-A Method for manufacturing semiconductor device and dicing die-bonding integrated film 株式会社力森诺科 2023-12-01 CN disclosed
WO-2023189424-A1 COMPOUND, CURABLE RESIN COMPOSITION AND CURED PRODUCT THEREFROM, AND METHOD FOR PRODUCING COMPOUND 日本化薬株式会社 2023-10-05 WO disclosed
WO-2023171592-A1 CURABLE RESIN COMPOSITION, RESIN SHEET, AND CURED PRODUCT OF SAME 日本化薬株式会社 2023-09-14 WO disclosed
US-4981768-A Photosensitive recording material having an N-aryl carbazole p-type charge transport compound AGFA-GEVAERT, N.V. (BE) 1991-01-01 US disclosed
US-4943502-A TWO LAYER SYSTEM OF CHARGE GENERATING AND CHARGE TRANSPORTING COMPOUNDS AGFA-GEVAERT, N.V. (BE) 1990-07-24 US disclosed
US-4937318-A Aromatic amine resins MITSUI TOATSU CHEMICALS, INC. (JP) 1990-06-26 US disclosed
EP-0347960-A1 Photosensitive recording material suited for use in electrophotography AGFA-GEVAERT N.V. (BE) 1989-12-27 EP disclosed
EP-0347967-A1 Photosensitive recording material suited for use in electrophotography AGFA-GEVAERT N.V. (BE) 1989-12-27 EP disclosed
CN-1032806-A Aromatic amine resin, its preparation method and application in thermosetting resin composition MITSUI TOATSU CHEMICALS (JP) 1989-05-10 CN disclosed
EP-0311387-A2 Aromatic amine resins, their production process and thermosetting resin compositions making use of the same MITSUI TOATSU CHEMICALS, Inc. (JP) 1989-04-12 EP disclosed
US-4053626-A CHOLESTEROL LEVEL-LOWERING PHENOXYACETIC ACIDS MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DT) 1977-10-11 US disclosed
US-4011375-A POLYOLEFINS THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF AGRICULTURE (US) 1977-03-08 US disclosed
US-3992386-A 4(Quinolyl)phenoxy alkanoic acid derivatives MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DT) 1976-11-16 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12605488-B2 Surface treatment methods for cementless implantable medical devices HAO2, BMP2, CASR ALDH1A1 3216/4885HPGD 2484/4885ALOX15 1379/4885
US-12616576-B2 Methods of modifying the porous surface of implants SLC11A2, VEGFA, MEF2D ALDH1A1 2696/4885HPGD 4098/4885ALOX15 2903/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.