Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 2/20 | 0.50 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 7/20 | 0.49 |
| ▸ | RAB9A | P51151 | 7/20 | 0.49 |
| ▸ | MITF | O75030 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 3/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.48 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8859224 | 1.00 | MTNR1A (0.50) | MTNR1AMTNR1BNPC1RAB9AMITF | |
| SCHEMBL8614756 | 1.00 | MTNR1A (0.50) | MTNR1AMTNR1BNPC1RAB9AMITF | |
| SCHEMBL17206059 | 0.88 | NPC1 (0.51) | MTNR1AMTNR1BNPC1RAB9AMITF | |
| SCHEMBL20213819 | 0.88 | NPC1 (0.51) | MTNR1AMTNR1BNPC1RAB9AMITF | |
| SCHEMBL519308 | 0.85 | MTNR1A (0.52) | MTNR1AMTNR1BNPC1RAB9AMITF | |
| SCHEMBL5168032 | 0.81 | CA1 (0.58) | NPC1RAB9ATP53SMN1; SMN2ALDH1A1 | |
| SCHEMBL5168035 | 0.81 | CA1 (0.58) | NPC1RAB9ATP53SMN1; SMN2ALDH1A1 | |
| SCHEMBL8015189 | 0.81 | CA1 (0.58) | NPC1RAB9ATP53SMN1; SMN2ALDH1A1 | |
| SCHEMBL28337467 | 0.81 | MAPT (0.51) | MTNR1AMTNR1BNPC1RAB9AMITF | |
| SCHEMBL9067633 | 0.80 | MAPT (0.70) | NPC1RAB9ATSHRSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7579472-B2 | Efficient synthesis of 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-08-25 | — | — | US | disclosed |
| US-20070282106-A1 | EFFICIENT SYNTHESIS OF 4,5-DIHYDRO-PYRAZOLO[3,4-c]PYRID-2-ONES | MUDRYK BOGUSLAW M | 2007-12-06 | — | — | US | disclosed |
| US-20070282106-A1 | EFFICIENT SYNTHESIS OF 4,5-DIHYDRO-PYRAZOLO[3,4-c]PYRID-2-ONES | MUDRYK BOGUSLAW M | 2007-12-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070282106-A1 | EFFICIENT SYNTHESIS OF 4,5-DIHYDRO-PYRAZOLO[3,4-c]PYRID-2-ONES | F2, TFPI, PDXK | MTNR1A 4591/4885MTNR1B 3843/4885NPC1 4572/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.