Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLS | O94925 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7357745 | 0.76 | KDM4E (0.43) | GLSKDM4EALDH1A1 | |
| SCHEMBL12871663 | 0.66 | KDM4E (0.49) | KDM4EALDH1A1 | |
| SCHEMBL13715650 | 0.64 | KDM4E (0.31) | KDM4E | |
| SCHEMBL7981164 | 0.62 | KDM4E (0.43) | GLSKDM4EALDH1A1 | |
| SCHEMBL13066525 | 0.61 | KDM4E (0.46) | GLSKDM4EALDH1A1 | |
| SCHEMBL13184316 | 0.61 | KDM4E (0.46) | GLSKDM4EALDH1A1 | |
| SCHEMBL13180563 | 0.59 | GLS (0.61) | GLSKDM4EALDH1A1 | |
| SCHEMBL21787372 | 0.58 | — | — | |
| SCHEMBL16200079 | 0.58 | KDM4E (0.40) | GLSKDM4EALDH1A1 | |
| SCHEMBL12871626 | 0.58 | CYP2C9 (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1531822-B1 | 1-ARYL-4-SUBSTITUTED PIPERAZINE DERIVATIVES FOR USE AS CCR1 ANTAGONISTS FOR THE TREATMENT OF INFLAMMATION AND IMMUNE DISORDERS | CHEMOCENTRYX INC (US) | 2009-08-05 | — | — | EP | disclosed |