Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NISCH | Q9Y2I1 | 3/20 | 0.37 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.36 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | AXL | P30530 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | KDM1A | O60341 | 3/20 | 0.32 |
| ▸ | MAOB | P27338 | 2/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28299833 | 0.63 | NISCH (0.44) | NISCHCHRNB4CHRNA3KDM4EALDH1A1 | |
| SCHEMBL1068403 | 0.62 | — | — | |
| SCHEMBL26984249 | 0.62 | CHRNB4 (0.38) | NISCHCHRNB4CHRNA3KDM4EMEN1 | |
| SCHEMBL895819 | 0.59 | CHRNB4 (0.67) | NISCHCHRNB4CHRNA3KDM4EALDH1A1 | |
| SCHEMBL7593570 | 0.59 | KDM1A (0.39) | NISCHALDH1A1KDM1AMAOBHSD17B10 | |
| SCHEMBL24799071 | 0.58 | NISCH (0.35) | NISCHCHRNB4CHRNA3ALDH1A1LMNA | |
| Biphenyl SCHEMBL27474545 | 0.58 | ALDH1A1 (0.56) | ALDH1A1CYP1A2LMNAKDM1AMAOB | |
| SCHEMBL24367106 | 0.57 | CHRNB4 (0.42) | NISCHCHRNB4CHRNA3KDM4EALDH1A1 | |
| SCHEMBL145371 | 0.56 | MAOB (0.44) | ALDH1A1CYP1A2LMNAKDM1AMAOB | |
| SCHEMBL14287876 | 0.56 | AXL (0.46) | CHRNB4CHRNA3KDM4EALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1249233-B9 | NPYY5 ANTAGONISTS | SHIONOGI & CO (JP) | 2009-08-05 | — | — | EP | disclosed |
| EP-1249233-B1 | NPYY5 ANTAGONISTS | SHIONOGI & CO (JP) | 2008-08-20 | — | — | EP | disclosed |