SCHEMBL895819

SCHEMBL895819

c1ccc(C2=NCC2)cc1

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRNB4 P30926 8/20 0.67
CHRNA3 P32297 8/20 0.67
CHRNA7 P36544 1/20 0.46
NPC1 O15118 3/20 0.43
RAB9A P51151 3/20 0.43
MAPK1 P28482 2/20 0.43
KDM4E B2RXH2 2/20 0.43
MAPT P10636 2/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
GLA P06280 1/20 0.43
TDP1 Q9NUW8 1/20 0.43
L3MBTL1 Q9Y468 1/20 0.43
NISCH Q9Y2I1 3/20 0.43
ALDH1A1 P00352 3/20 0.42
CYP1A2 P05177 1/20 0.42
THRB P10828 1/20 0.42
CYP2C19 P33261 1/20 0.42
GAA P10253 2/20 0.40
AXL P30530 1/20 0.40
TSHR P16473 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL165812 0.82 CHRNB4 (0.87) CHRNB4CHRNA3CHRNA7NPC1RAB9A
SCHEMBL895500 0.80 CHRNB4 (1.00) CHRNB4CHRNA3CHRNA7RAB9AMAPT
SCHEMBL6797483 0.79 CHRNB4 (0.96) CHRNB4CHRNA3CHRNA7RAB9AMAPT
SCHEMBL1068403 0.77
SCHEMBL22482394 0.74 CHRNB4 (0.45) CHRNB4CHRNA3CHRNA7NPC1RAB9A
SCHEMBL24367106 0.70 CHRNB4 (0.42) CHRNB4CHRNA3CHRNA7NPC1RAB9A
SCHEMBL25319908 0.69 CHRNB4 (0.46) CHRNB4CHRNA3NPC1RAB9AMAPK1
SCHEMBL25319906 0.69 CHRNB4 (0.46) CHRNB4CHRNA3NPC1RAB9AMAPK1
SCHEMBL2282129 0.69 NISCH (0.44) CHRNB4CHRNA3NPC1RAB9AMAPK1
SCHEMBL14287876 0.69 AXL (0.46) CHRNB4CHRNA3NPC1RAB9AMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11389464-B2 Arginase inhibitors as therapeutics MARS, INCORPORATED (US) 2022-07-19 US disclosed
EP-3719024-A1 ARGINASE INHIBITORS AS THERAPEUTICS Mars, Incorporated (US) 2020-10-07 EP disclosed
US-20200246362-A1 Arginase Inhibitors as Therapeutics MARS, INCORPORATED 2020-08-06 US disclosed
EP-3034509-B1 ARGINASE INHIBITORS AS THERAPEUTICS MARS INC (US) 2020-04-22 EP disclosed
US-10603330-B2 Arginase inhibitors as therapeutics MARS, INCORPORATED (US) 2020-03-31 US disclosed
US-20190054101-A1 ARGINASE INHIBITORS AS THERAPEUTICS MARS, INCORPORATED 2019-02-21 US disclosed
EP-2560978-B1 INHIBITORS OF ARGINASE AND THEIR THERAPEUTIC APPLICATIONS MARS INC (US) 2019-01-30 EP disclosed
US-20180296532-A1 RNA-Focused Small Molecules for Inhibiting RNA Toxicity in Myotonic Dystrophy SCRIPPS RESEARCH INST (US) 2018-10-18 US disclosed
US-10098902-B2 Arginase inhibitors as therapeutics MARS, INCORPORATED (US) 2018-10-16 US disclosed
US-20180251479-A1 INHIBITORS OF ARGINASE AND THEIR THERAPEUTIC APPLICATIONS MARS, INCORPORATED 2018-09-06 US disclosed
US-20150191492-A1 ARGINASE INHIBITORS AS THERAPEUTICS MARS, INCORPORATED 2015-07-09 US disclosed
US-9040703-B2 Inhibitors of arginase and their therapeutic applications MARS, INCORPORATED (US) 2015-05-26 US disclosed
US-20140371175-A1 INHIBITORS OF ARGINASE AND THEIR THERAPEUTIC APPLICATIONS MARS, INCORPORATED 2014-12-18 US disclosed
EP-2632927-A1 BORONATES AS ARGINASE INHIBITORS Mars, Incorporated (US) 2013-09-04 EP disclosed
EP-2560978-A1 INHIBITORS OF ARGINASE AND THEIR THERAPEUTIC APPLICATIONS Mars, Incorporated (US) 2013-02-27 EP disclosed
US-20120149708-A1 MODULATORS OF VIRAL TRANSCRIPTION, AND METHODS AND COMPOSITIONS THEREWITH GEORGE MASON UNIVERSITY 2012-06-14 US disclosed
US-20120129806-A1 ARGINASE INHIBITORS AS THERAPEUTICS MARS, INCORPORATED 2012-05-24 US disclosed
WO-2012058065-A1 BORONATES AS ARGINASE INHIBITORS MARS INCORPORATED (US) 2012-05-03 WO disclosed
US-20120083469-A1 INHIBITORS OF ARGINASE AND THEIR THERAPEUTIC APPLICATIONS MARS, INCORPORATED 2012-04-05 US disclosed
WO-2011133653-A1 INHIBITORS OF ARGINASE AND THEIR THERAPEUTIC APPLICATIONS MARS, INCORPORATED (US) 2011-10-27 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (12 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11389464-B2 Arginase inhibitors as therapeutics ARG1, ARG2, PRMT1 CHRNB4 3003/4885CHRNA3 2610/4885CHRNA7 2789/4885
US-10603330-B2 Arginase inhibitors as therapeutics ARG1, ARG2, PRMT1 CHRNB4 3003/4885CHRNA3 2610/4885CHRNA7 2789/4885
US-20180251479-A1 INHIBITORS OF ARGINASE AND THEIR THERAPEUTIC APPLICATIONS ARG1, ARG2, PRMT9 CHRNB4 3020/4885CHRNA3 2163/4885CHRNA7 1749/4885
US-20180296532-A1 RNA-Focused Small Molecules for Inhibiting RNA Toxicity in Myotonic Dystrophy NSUN3, EMG1, RBM3 CHRNB4 2395/4885CHRNA3 2257/4885CHRNA7 2972/4885
US-20120129806-A1 ARGINASE INHIBITORS AS THERAPEUTICS ARG1, ARG2, PRMT1 CHRNB4 3003/4885CHRNA3 2610/4885CHRNA7 2789/4885
US-20200246362-A1 Arginase Inhibitors as Therapeutics ARG1, ARG2, PRMT1 CHRNB4 3003/4885CHRNA3 2610/4885CHRNA7 2789/4885
US-20120149708-A1 MODULATORS OF VIRAL TRANSCRIPTION, AND METHODS AND COMPOSITIONS THEREWITH CDK2, CCNA1, CDK1 CHRNB4 4372/4885CHRNA3 4163/4885CHRNA7 4044/4885
US-10098902-B2 Arginase inhibitors as therapeutics ARG1, ARG2, PRMT1 CHRNB4 3003/4885CHRNA3 2610/4885CHRNA7 2789/4885
US-20150191492-A1 ARGINASE INHIBITORS AS THERAPEUTICS ARG1, ARG2, PRMT1 CHRNB4 3003/4885CHRNA3 2610/4885CHRNA7 2789/4885
US-20120083469-A1 INHIBITORS OF ARGINASE AND THEIR THERAPEUTIC APPLICATIONS ARG1, ARG2, PRMT9 CHRNB4 3020/4885CHRNA3 2163/4885CHRNA7 1749/4885
US-20190054101-A1 ARGINASE INHIBITORS AS THERAPEUTICS ARG1, ARG2, PRMT1 CHRNB4 3003/4885CHRNA3 2610/4885CHRNA7 2789/4885
US-20140371175-A1 INHIBITORS OF ARGINASE AND THEIR THERAPEUTIC APPLICATIONS ARG1, ARG2, PRMT9 CHRNB4 3020/4885CHRNA3 2163/4885CHRNA7 1749/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.