Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | DTYMK | P23919 | 1/20 | 0.46 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.42 |
| ▸ | CCNK | O75909 | 1/20 | 0.40 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.40 |
| ▸ | CKS1B | P61024 | 1/20 | 0.40 |
| ▸ | SKP1 | P63208 | 1/20 | 0.40 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.40 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.39 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.38 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.38 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3764320 | 0.81 | PIK3CA (0.51) | POLBDTYMKGPR119DDB1CRBN | |
| SCHEMBL27713892 | 0.74 | FEN1 (0.40) | — | |
| SCHEMBL26671857 | 0.73 | GPR119 (0.49) | POLBDTYMKGPR119DDB1CRBN | |
| SCHEMBL23293467 | 0.72 | POLB (0.49) | POLBDTYMKGPR119CHRM2CHRM4 | |
| SCHEMBL2715768 | 0.70 | POLB (0.57) | POLBDTYMKGPR119CKS1BSKP1 | |
| SCHEMBL31046329 | 0.70 | POLB (0.57) | POLBDTYMKGPR119CKS1BSKP1 | |
| SCHEMBL30339737 | 0.70 | DDB1 (0.55) | POLBDTYMKGPR119CHRM2CHRM4 | |
| SCHEMBL24101859 | 0.70 | DDB1 (0.55) | POLBDTYMKGPR119CHRM2CHRM4 | |
| SCHEMBL30292496 | 0.69 | POLB (0.56) | POLBDTYMKGPR119CKS1BSKP1 | |
| SCHEMBL10317314 | 0.69 | POLB (0.58) | POLBDTYMKGPR119CKS1BSKP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2524917-B1 | FUSED PYRIDINE DERIVATIVES | SIHUAN PHARMACEUTICAL HOLDINGS GROUP LTD (CN) | 2018-06-27 | — | — | EP | disclosed |
| US-8680089-B2 | Fused pyridine derivatives | Xuanzhu Pharma Co., Ltd. (CN) | 2014-03-25 | — | — | US | disclosed |
| EP-2524917-A1 | FUSED PYRIDINE DERIVATIVES | Xuanzhu Pharmaco., Ltd. (CN) | 2012-11-21 | — | — | EP | disclosed |
| US-20120289497-A1 | FUSED PYRIDINE DERIVATIVES | Xuanzhu Pharma Co., Ltd. (CN) | 2012-11-15 | — | — | US | disclosed |
| CN-102127072-A | Pyridine cyclo-derivative | SHANDONG XUANZHU PHARMACEUTICAL CO LTD | 2011-07-20 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120289497-A1 | FUSED PYRIDINE DERIVATIVES | GPR119, INSR, IAPP | POLB 3339/4885DTYMK 3156/4885GPR119 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.