Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | ESR1 | P03372 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 5/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3812669 | 0.87 | P2RX7 (0.48) | HDAC6ALDH1A1TSHRKDM4ENPC1 | |
| SCHEMBL3813487 | 0.85 | GABRG2 (0.43) | HDAC6ALDH1A1TSHRKDM4ENPC1 | |
| SCHEMBL3820186 | 0.82 | NAMPT (0.44) | ALDH1A1TSHRKDM4ENPC1HTT | |
| SCHEMBL3820000 | 0.82 | SCD (0.50) | ALDH1A1TSHRKDM4ENPC1HTT | |
| SCHEMBL3821362 | 0.80 | ALDH1A1 (0.41) | HDAC6ALDH1A1TSHRESR2TDP1 | |
| SCHEMBL3815154 | 0.79 | ALDH1A1 (0.38) | HDAC6ALDH1A1TSHRKDM4ENPC1 | |
| SCHEMBL3813994 | 0.78 | P2RX7 (0.51) | ALDH1A1TSHRKDM4ENPC1HTT | |
| SCHEMBL3820194 | 0.78 | GRM5 (0.41) | HDAC6ALDH1A1TSHRKDM4ENPC1 | |
| SCHEMBL3818093 | 0.77 | P2RX7 (0.43) | ALDH1A1TSHRESR2TDP1ESR1 | |
| SCHEMBL3816360 | 0.76 | ALDH1A1 (0.40) | HDAC6ALDH1A1TSHRKDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2090576-A1 | 6-halo-pyrazolo[1,5-a]pyridines, a process for their preparation and their use as metabotropic glutamate receptor (mGluR) modulators | Merz Pharma GmbH & Co.KGaA (DE) | 2009-08-19 | — | — | EP | disclosed |