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Thioproperazine

Thioproperazine

SCHEMBL13723252

CCCC(=O)c1ccc2c(c1)N(CCCN1CCN(C)CC1)c1ccccc1S2.CN1CCN(CCCN2c3ccccc3Sc3ccc(S(=O)(=O)N(C)C)cc32)CC1

nearest known ligand 0.79

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ DRD3 P35462 7/20 0.79
▸ DRD2 P14416 7/20 0.79
▸ HRH1 P35367 7/20 0.79
▸ HTR1A P08908 6/20 0.79
▸ ADRA2A P08913 6/20 0.79
▸ DRD1 P21728 6/20 0.79
▸ SLC6A2 P23975 6/20 0.79
▸ ADRA1A P35348 6/20 0.79
▸ SLC6A3 Q01959 6/20 0.79
▸ KCNH2 Q12809 6/20 0.79
▸ CHRM1 P11229 5/20 0.79
▸ ADRA2C P18825 5/20 0.79
▸ HTR2A P28223 5/20 0.79
▸ SLC6A4 P31645 5/20 0.79
▸ CHRM2 P08172 4/20 0.79
▸ OPRM1 P35372 4/20 0.79
▸ ADRA2B P18089 4/20 0.79
▸ HRH3 Q9Y5N1 4/20 0.79
▸ TBXA2R P21731 3/20 0.79
▸ CHRM3 P20309 3/20 0.79

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Butaperazine SCHEMBL119995 0.90 HRH1 (0.67) DRD3DRD2HRH1HTR1AADRA2A
Butaperazine SCHEMBL31153317 0.90 HRH1 (0.67) DRD3DRD2HRH1HTR1AADRA2A
Butaperazine SCHEMBL28086241 0.90 HRH1 (0.67) DRD3DRD2HRH1HTR1AADRA2A
Butaperazine SCHEMBL29710903 0.90 HRH1 (0.67) DRD3DRD2HRH1HTR1AADRA2A
Thioproperazine SCHEMBL29372322 0.89 DRD3 (1.00) DRD3DRD2HRH1HTR1AADRA2A
Thioproperazine SCHEMBL29394708 0.89 DRD3 (1.00) DRD3DRD2HRH1HTR1AADRA2A
Thioproperazine SCHEMBL49902 0.89 DRD3 (1.00) DRD3DRD2HRH1HTR1AADRA2A
Thioproperazine SCHEMBL29888916 0.87 CYP3A4 (1.00) DRD3DRD2HRH1HTR1AADRA2A
Thioproperazine SCHEMBL2386850 0.87 CYP3A4 (1.00) DRD3DRD2HRH1HTR1AADRA2A
Thioproperazine SCHEMBL3027811 0.87 CYP3A4 (1.00) DRD3DRD2HRH1HTR1AADRA2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-103717597-B Heterocyclic compounds as kinase inhibitors 原真股份有限公司 2017-07-04 — — CN disclosed
EP-2699572-A1 HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS Origenis GmbH (DE) 2014-02-26 — — EP disclosed
EP-2699579-A1 PYRAZOLO [4, 3-D]PYRIMIDINES USEFUL AS KINASE INHIBITORS Origenis GmbH (DE) 2014-02-26 — — EP disclosed
WO-2012143144-A1 PYRAZOLO [4, 3-D] PYRIMIDINES USEFUL AS KINASE INHIBITORS ORIGENIS GMBH (DE) 2012-10-26 — — WO disclosed
WO-2012143143-A1 HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS ORIGENIS GMBH (DE) 2012-10-26 — — WO disclosed