Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 7/20 | 0.67 |
| ▸ | HTR1A | P08908 | 6/20 | 0.67 |
| ▸ | DRD2 | P14416 | 6/20 | 0.67 |
| ▸ | ADRA2C | P18825 | 6/20 | 0.67 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.67 |
| ▸ | HTR2A | P28223 | 6/20 | 0.67 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.67 |
| ▸ | ADRA1A | P35348 | 6/20 | 0.67 |
| ▸ | DRD3 | P35462 | 6/20 | 0.67 |
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.67 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.67 |
| ▸ | ADRA2A | P08913 | 5/20 | 0.67 |
| ▸ | DRD1 | P21728 | 5/20 | 0.67 |
| ▸ | ADRA2B | P18089 | 5/20 | 0.67 |
| ▸ | HTR2B | P41595 | 4/20 | 0.67 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.67 |
| ▸ | MLNR | O43193 | 2/20 | 0.67 |
| ▸ | ESR1 | P03372 | 2/20 | 0.67 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.67 |
| ▸ | KDM1A | O60341 | 3/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Butaperazine SCHEMBL119995 | 1.00 | HRH1 (0.67) | HRH1HTR1ADRD2ADRA2CSLC6A2 | |
| Butaperazine SCHEMBL29710903 | 1.00 | HRH1 (0.67) | HRH1HTR1ADRD2ADRA2CSLC6A2 | |
| Butaperazine SCHEMBL31153317 | 1.00 | HRH1 (0.67) | HRH1HTR1ADRD2ADRA2CSLC6A2 | |
| Butaperazine SCHEMBL120744 | 0.94 | LMNA (0.72) | HRH1HTR1ADRD2ADRA2CSLC6A2 | |
| Butaperazine SCHEMBL120743 | 0.94 | LMNA (0.72) | HRH1HTR1ADRD2ADRA2CSLC6A2 | |
| Thioproperazine SCHEMBL13723252 | 0.90 | DRD3 (0.79) | HRH1HTR1ADRD2ADRA2CSLC6A2 | |
| SCHEMBL18309819 | 0.88 | HRH1 (0.69) | HRH1HTR1ADRD2ADRA2CSLC6A2 | |
| SCHEMBL141601 | 0.87 | HTR1A (0.86) | HRH1HTR1ADRD2ADRA2CSLC6A2 | |
| SCHEMBL26837052 | 0.85 | HRH1 (0.69) | HRH1HTR1ADRD2ADRA2CSLC6A2 | |
| Carphenazine SCHEMBL1458434 | 0.84 | HRH1 (0.81) | HRH1HTR1ADRD2ADRA2CSLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103717597-B | Heterocyclic compounds as kinase inhibitors | 原真股份有限公司 | 2017-07-04 | — | — | CN | disclosed |
| CN-103492389-B | Pyrazolo [4,3-d] pyrimidine as inhibitors of kinases | 原真股份有限公司 | 2016-09-14 | — | — | CN | disclosed |