Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | HTT | P42858 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | GBA1 | P04062 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13724345 | 0.91 | LMNA (0.47) | LMNAHTTSMN1; SMN2NPSR1KDM4E | |
| SCHEMBL3825392 | 0.91 | PKM (0.39) | LMNAKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL3825309 | 0.90 | ATM (0.44) | ATMLMNAHTTSMN1; SMN2NPSR1 | |
| SCHEMBL3817436 | 0.89 | CFTR (0.47) | LMNAHTTSMN1; SMN2TSHRKDM4E | |
| SCHEMBL3821683 | 0.89 | GBA1 (0.44) | ATMLMNAHTTSMN1; SMN2NPSR1 | |
| SCHEMBL15457091 | 0.88 | LMNA (0.47) | ATMLMNAHTTSMN1; SMN2NPSR1 | |
| SCHEMBL15457123 | 0.87 | HTT (0.45) | ATMLMNAHTTSMN1; SMN2NPSR1 | |
| SCHEMBL3819862 | 0.87 | S1PR1 (0.45) | ATMLMNAHTTSMN1; SMN2NPSR1 | |
| SCHEMBL15457180 | 0.87 | S1PR1 (0.46) | ATMLMNAHTTSMN1; SMN2NPSR1 | |
| SCHEMBL15457092 | 0.87 | PKM (0.43) | ATMLMNAHTTSMN1; SMN2NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1646615-B1 | PYRIMIDINE DERIVATIVES AS MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | VERTEX PHARMA (US) | 2009-08-26 | — | — | EP | disclosed |