Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | GAA | P10253 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 4/20 | 0.41 |
| ▸ | METAP1 | P53582 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GBA1 | P04062 | 4/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13723945 | 0.91 | ATM (0.43) | LMNAGAAKDM4EALDH1A1HTT | |
| SCHEMBL3825392 | 0.91 | PKM (0.39) | LMNAGAAKDM4EPKMALDH1A1 | |
| SCHEMBL3817436 | 0.90 | CFTR (0.47) | LMNAKDM4EHSD11B1PKMALDH1A1 | |
| SCHEMBL3820012 | 0.89 | LMNA (0.48) | LMNAGAAKDM4EHSD11B1PKM | |
| SCHEMBL15457091 | 0.89 | LMNA (0.47) | LMNAGAAKDM4EHSD11B1PKM | |
| SCHEMBL3820657 | 0.89 | GAA (0.47) | LMNAGAAKDM4EHSD11B1PKM | |
| SCHEMBL15457177 | 0.87 | CFTR (0.46) | LMNAGAAKDM4EHSD11B1PKM | |
| SCHEMBL15457062 | 0.86 | HSD11B1 (0.52) | LMNAGAAKDM4EHSD11B1METAP1 | |
| SCHEMBL3823767 | 0.86 | GPR6 (0.47) | LMNAGAAKDM4EHSD11B1PKM | |
| SCHEMBL15457294 | 0.84 | GAA (0.46) | LMNAGAAKDM4EHSD11B1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1646615-B1 | PYRIMIDINE DERIVATIVES AS MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | VERTEX PHARMA (US) | 2009-08-26 | — | — | EP | disclosed |