Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Cyclizine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 1/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 4/20 | 1.00 |
| ▸ | CHRM2 | P08172 | 3/20 | 1.00 |
| ▸ | ADRA2A | P08913 | 3/20 | 1.00 |
| ▸ | CHRM1 | P11229 | 3/20 | 1.00 |
| ▸ | DRD1 | P21728 | 3/20 | 1.00 |
| ▸ | DRD3 | P35462 | 3/20 | 1.00 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 3/20 | 1.00 |
| ▸ | OPRM1 | P35372 | 3/20 | 1.00 |
| ▸ | CHRM4 | P08173 | 1/20 | 1.00 |
| ▸ | CHRM5 | P08912 | 1/20 | 1.00 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 1.00 |
| ▸ | CHRM3 | P20309 | 1/20 | 1.00 |
| ▸ | ADRA1D | P25100 | 1/20 | 1.00 |
| ▸ | HTR2A | P28223 | 1/20 | 1.00 |
| ▸ | HTR2C | P28335 | 1/20 | 1.00 |
| ▸ | HTR2B | P41595 | 1/20 | 1.00 |
| ▸ | HTR1A | P08908 | 2/20 | 0.79 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.79 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cyclizine SCHEMBL97825 | 0.98 | CYP2D6 (0.96) | CYP2D6CHRM2ADRA2ACHRM1DRD1 | |
| Cyclizine SCHEMBL19514707 | 0.98 | CYP2D6 (0.96) | CYP2D6CHRM2ADRA2ACHRM1DRD1 | |
| Cyclizine SCHEMBL97826 | 0.96 | CYP2D6 (0.92) | CYP2D6CHRM2ADRA2ACHRM1DRD1 | |
| Cyclizine SCHEMBL5656056 | 0.91 | CYP2D6 (0.82) | CYP2D6CHRM2ADRA2ACHRM1DRD1 | |
| SCHEMBL12359491 | 0.89 | CHRM1 (0.79) | CYP2D6CHRM2ADRA2ACHRM1DRD1 | |
| Chlorcyclizine SCHEMBL4383 | 0.89 | KCNH2 (1.00) | CYP2D6CHRM2ADRA2ACHRM1DRD1 | |
| SCHEMBL2615164 | 0.89 | CYP2D6 (0.79) | CYP2D6CHRM2ADRA2ACHRM1DRD1 | |
| Chlorcyclizine SCHEMBL12157065 | 0.89 | KCNH2 (1.00) | CYP2D6CHRM2ADRA2ACHRM1DRD1 | |
| Chlorcyclizine SCHEMBL16769331 | 0.89 | KCNH2 (1.00) | CYP2D6CHRM2ADRA2ACHRM1DRD1 | |
| Chlorcyclizine SCHEMBL13724147 | 0.89 | KCNH2 (1.00) | CYP2D6CHRM2ADRA2ACHRM1DRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 14422 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4704971-A1 | GAMMA STIMULATION AND NEUROMODULATOR COMBINATION THERAPY | Cognito Therapeutics, Inc. (US) | 2026-03-11 | — | — | EP | claimed |
| US-12569451-B2 | Bio-inspired tissue-adhesive hydrogel patch and uses thereof | Cellartgen Inc. (KR) | 2026-03-10 | — | — | US | claimed |
| EP-4658240-A2 | PHARMACEUTICAL COMPOSITIONS FOR NASAL DELIVERY | Therakind Limited (GB) | 2025-12-10 | — | — | EP | claimed |
| EP-4630401-A2 | CARBONIC ANHYDRASE ENZYME INHIBITORS AND METHODS OF USE THEREOF | Rutgers, the State University of New Jersey (US) | 2025-10-15 | — | — | EP | claimed |
| US-20250248940-A1 | Biopolymer Formulations for Drug Delivery | 11584022 CANADA INC. (CA) | 2025-08-07 | — | — | US | claimed |
| WO-2025136243-A1 | MECHANOCHEMICAL SYNTHESIS OF HISTAMINE H1-RECEPTOR ANTAGONISTS | IHSAN DOGRAMACI BILKENT UNIVERSITESI (TR) | 2025-06-26 | — | — | WO | claimed |
| US-20250177398-A1 | CARBONIC ANHYDRASE ENZYMES FOR REGULATING MAST CELL HEMATOPOIESIS AND TYPE 2 INFLAMMATION | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2025-06-05 | — | — | US | claimed |
| WO-2025111482-A1 | COMPLEXING AGENT SALT FORMULATIONS OF PHARMACEUTICAL COMPOUNDS AT LOW STOICHIOMETRIC RATIOS | BEXSON BIOMEDICAL, INC. (US) | 2025-05-30 | — | — | WO | claimed |
| WO-2025101989-A1 | MEDICATION TO ALLEVIATE NAUSEA WITH OR WITHOUT VOMITING, VERTIGO, AND PAIN | MYSLINSKI LISA (US) | 2025-05-15 | — | — | WO | claimed |
| US-20250152595-A1 | MEDICATION TO ALLEVIATE NAUSEA WITH OR WITHOUT VOMITING, VERTIGO, AND PAIN | MYSLINSKI LISA (US) | 2025-05-15 | — | — | US | claimed |
| EP-0426479-A1 | Use of a composition for the manufacture of a medicament for curing the symptoms of overindulgence | McNEIL-PPC, INC. (US) | 1991-05-08 | — | — | EP | claimed |
| US-4996047-A | Sustained release drug-resin complexes | RICHARDSON-VICKS, INC. (US) | 1991-02-26 | — | — | US | claimed |
| WO-1991001132-A1 | CHEWING GUM COMPOSITION WITH ACCELERATED, CONTROLLED RELEASE OF ACTIVE AGENTS | FERTIN LABORATORIES LTD. (DANSK TYGGEGUMMI FABRIK A/S) (DK) | 1991-02-07 | — | — | WO | claimed |
| EP-0367746-A2 | Sustained release drug-resin complexes | RICHARDSON-VICKS, INC. (US) | 1990-05-09 | — | — | EP | claimed |
| US-4729997-A | ANTIEMETICS, ANTIHISTAMINES | NASTECH PHARMACEUTICAL CO., INC. (US) | 1988-03-08 | — | — | US | claimed |
| EP-0201537-A4 | NOVEL USE OF ANTI-NAUSEA AND ANTI-EMETIC PHARMAZEUTICAL AGENTS. | NASTECH PHARM CO (US) | 1987-07-06 | — | — | EP | claimed |
| EP-0201537-A1 | NOVEL USE OF ANTI-NAUSEA AND ANTI-EMETIC PHARMAZEUTICAL AGENTS. | NASTECH PHARM CO (US) | 1986-11-20 | — | — | EP | claimed |
| WO-1986002553-A1 | NOVEL METHOD OF ADMINISTERING ANTI-NAUSEA AND ANTI-EMETIC PHARMACEUTICAL AGENTS AND NOVEL DOSAGE FORMS CONTAINING SAME | NASTECH PHARMACEUTICAL COMPANY, INC. (US) | 1986-05-09 | — | — | WO | claimed |
| EP-0097340-A2 | Piperazine derivatives, a process for preparing them and pharmaceutical compositions | FERRER INTERNACIONAL, S.A. (ES) | 1984-01-04 | — | — | EP | claimed |
| US-3940485-A | Treatment and pre-treatment of dysmetric dyslexia by improving sequential scanning and ocular fixation abilities and therapeutic compounds | LEVINSON HAROLD N | 1976-02-24 | — | — | US | claimed |