Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.63 |
| ▸ | ECE1 | P42892 | 1/20 | 0.62 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.59 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.54 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.53 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | PLOD2 | O00469 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | APP | P05067 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28865879 | 0.91 | ECE1 (0.56) | THRBECE1HDAC1HDAC6LMNA | |
| SCHEMBL16322351 | 0.91 | ECE1 (0.56) | THRBECE1HDAC1HDAC6LMNA | |
| SCHEMBL24298437 | 0.88 | LMNA (0.54) | THRBECE1HDAC1HDAC6LMNA | |
| SCHEMBL29421299 | 0.88 | LMNA (0.54) | THRBECE1HDAC1HDAC6LMNA | |
| SCHEMBL29995369 | 0.85 | ECE1 (0.60) | THRBECE1HDAC1HDAC6LMNA | |
| SCHEMBL24267375 | 0.85 | ECE1 (0.60) | THRBECE1HDAC1HDAC6LMNA | |
| SCHEMBL30557508 | 0.84 | LMNA (0.67) | THRBECE1HDAC1HDAC6LMNA | |
| SCHEMBL28115691 | 0.84 | LMNA (0.67) | THRBECE1HDAC1HDAC6LMNA | |
| SCHEMBL2793049 | 0.83 | THRB (0.58) | THRBECE1HDAC1HDAC6LMNA | |
| SCHEMBL2794612 | 0.83 | THRB (0.58) | THRBECE1HDAC1HDAC6LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3852758-A1 | COMBINATIONS OF TGFB INHIBITORS AND CDK INHIBITORS FOR THE TREATMENT OF BREAST CANCER | Pfizer Inc. (US) | 2021-07-28 | — | — | EP | claimed |
| WO-2020058820-A1 | COMBINATIONS OF TGFB INHIBITORS AND CDK INHIBITORS FOR THE TREATMENT OF BREAST CANCER | PFIZER INC. (US) | 2020-03-26 | — | — | WO | claimed |
| WO-2022229846-A1 | TREATMENT OF CANCER USING A TRANSFORMING GROWTH FACTOR BETA RECEPTOR TYPE 1 INHIBITOR | PFIZER INC. (US) | 2022-11-03 | — | — | WO | disclosed |
| WO-2022130206-A1 | TGFβr1 INHIBITOR COMBINATION THERAPIES | PFIZER INC. (US) | 2022-06-23 | — | — | WO | disclosed |
| CN-112843058-A | Application of nicotinamide compound in preparation of anti-spinal cord tumor drug | 复旦大学附属华山医院 | 2021-05-28 | — | — | CN | disclosed |
| WO-2020055153-A1 | NOVEL SERINOL-BASED COMPOUND, AND COSMETIC AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME | 닥터 레이몬드 래보라토리 | 2020-03-19 | — | — | WO | disclosed |
| CN-106132950-A | Compounds and methods of use | 麦迪韦逊技术股份有限公司 | 2016-11-16 | — | — | CN | disclosed |
| EP-2699551-A1 | TETRAHYDROQUINOLINE DERIVATIVES USEFUL AS BROMODOMAIN INHIBITORS | Glaxosmithkline LLC (US) | 2014-02-26 | — | — | EP | disclosed |
| WO-2012143415-A1 | TETRAHYDROQUINOLINE DERIVATIVES USEFUL AS BROMODOMAIN INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2012-10-26 | — | — | WO | disclosed |