Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Trimethadione. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.83 |
| ▸ | ELANE | P08246 | 3/20 | 0.37 |
| ▸ | PRTN3 | P24158 | 3/20 | 0.37 |
| ▸ | CTSG | P08311 | 2/20 | 0.37 |
| ▸ | PGR | P06401 | 2/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trimethadione SCHEMBL28882 | 0.91 | LMNA (1.00) | LMNAELANEPRTN3CTSGPGR | |
| Paramethadione SCHEMBL23832172 | 0.76 | LMNA (0.70) | LMNAELANEPRTN3CTSGPGR | |
| Ethadione SCHEMBL13724326 | 0.76 | LMNA (0.70) | LMNAELANEPRTN3CTSGPGR | |
| Metharbital SCHEMBL4885996 | 0.70 | LMNA (0.59) | LMNAELANEPRTN3CTSG | |
| SCHEMBL1362309 | 0.68 | LMNA (0.60) | LMNA | |
| SCHEMBL4757604 | 0.68 | LMNA (0.48) | LMNAELANEPRTN3CTSGAR | |
| SCHEMBL676775 | 0.68 | LMNA (0.54) | LMNA | |
| SCHEMBL4755116 | 0.67 | ELANE (0.50) | LMNAELANEPRTN3CTSGAR | |
| SCHEMBL14404412 | 0.65 | LMNA (0.56) | LMNAELANEPRTN3CTSGAR | |
| Paramethadione SCHEMBL317346 | 0.65 | LMNA (0.56) | LMNAELANEPRTN3CTSGPGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2699572-A1 | HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS | Origenis GmbH (DE) | 2014-02-26 | — | — | EP | disclosed |
| EP-2699579-A1 | PYRAZOLO [4, 3-D]PYRIMIDINES USEFUL AS KINASE INHIBITORS | Origenis GmbH (DE) | 2014-02-26 | — | — | EP | disclosed |
| WO-2012143144-A1 | PYRAZOLO [4, 3-D] PYRIMIDINES USEFUL AS KINASE INHIBITORS | ORIGENIS GMBH (DE) | 2012-10-26 | — | — | WO | disclosed |
| WO-2012143143-A1 | HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS | ORIGENIS GMBH (DE) | 2012-10-26 | — | — | WO | disclosed |