Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Trimethadione. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 1.00 |
| ▸ | ELANE | P08246 | 3/20 | 0.41 |
| ▸ | PRTN3 | P24158 | 3/20 | 0.41 |
| ▸ | CTSG | P08311 | 2/20 | 0.41 |
| ▸ | PGR | P06401 | 3/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.32 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trimethadione SCHEMBL13724328 | 0.91 | LMNA (0.83) | LMNAELANEPRTN3CTSGPGR | |
| Ethadione SCHEMBL13724326 | 0.84 | LMNA (0.70) | LMNAELANEPRTN3CTSGPGR | |
| Metharbital SCHEMBL4885996 | 0.77 | LMNA (0.59) | LMNAELANEPRTN3CTSG | |
| SCHEMBL1362309 | 0.75 | LMNA (0.60) | LMNAPTGER3 | |
| SCHEMBL14404412 | 0.72 | LMNA (0.56) | LMNAELANEPRTN3CTSGAR | |
| Paramethadione SCHEMBL317346 | 0.72 | LMNA (0.56) | LMNAELANEPRTN3CTSGPGR | |
| SCHEMBL1363134 | 0.70 | LMNA (0.54) | LMNA | |
| SCHEMBL14009928 | 0.70 | LMNA (0.54) | LMNAELANEPRTN3CTSGPGR | |
| SCHEMBL676775 | 0.70 | LMNA (0.54) | LMNA | |
| SCHEMBL5006337 | 0.69 | ELANE (0.54) | LMNAELANEPRTN3CTSGAR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 6440 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122080848-A | Polyether amine modified polyimide binder and preparation method and application thereof | — | 2026-05-26 | — | — | CN | claimed |
| CN-119945423-A | Gain adjusting circuit of voltage-controlled oscillator of charge pump phase-locked loop and charge pump phase-locked loop | 纳能微电子(成都)股份有限公司 | 2025-05-06 | — | — | CN | claimed |
| US-12285488-B2 | Oral dosage form containing theobromine-free cocoa | LTS LOHMANN THERAPIE-SYSTEME AG (DE) | 2025-04-29 | — | — | US | claimed |
| EP-3518975-B1 | FORMULATION COMPRISING FENFLURAMINE AND CANNABIDIOL AND ITS USE IN THE TREATMENT OF SEIZURES | ZOGENIX INTERNATIONAL LTD (GB) | 2025-04-09 | — | — | EP | claimed |
| CN-119345392-A | Method for improving medicine solubility and medicine composite material with enhanced solubility | 药容科技有限公司 | 2025-01-24 | — | — | CN | claimed |
| CN-221974125-U | Concave-convex type in-line slider coupler | 广东中南钢铁股份有限公司 | 2024-11-08 | — | — | CN | claimed |
| CN-118812589-A | Trialkylphosphine oxide compound derivative and preparation method thereof | 北京大学 | 2024-10-22 | — | — | CN | claimed |
| EP-4408484-A1 | MULTIFUNCTIONAL COMPOUNDS FOR USE IN MEDICAL IMAGING AND THERAPY | Antelope Surgical Solutions, Inc. (US) | 2024-08-07 | — | — | EP | claimed |
| US-20240216409-A1 | Patient Treatment Via Teratogenic Pharmaceutical Compounds | NANT HOLDINGS IP, LLC (US) | 2024-07-04 | — | — | US | claimed |
| CN-117945824-A | Deuterated methyl enaminone compound and preparation method thereof | 南京工业大学 | 2024-04-30 | — | — | CN | claimed |
| WO-1998007447-A1 | ANTICONVULSANT CONTAINING COMPOSITION FOR TREATING NEUROPATHIC PAIN | ALGOS PHARMACEUTICAL CORPORATION (US) | 1998-02-26 | — | — | WO | claimed |
| US-5688510-A | POWDER, MACROLOLECULAR ADDITIVE | NIPPON SHINYAKU CO. LTD. (JP) | 1997-11-18 | — | — | US | claimed |
| EP-0758228-A1 | EFFECTIVE DOSAGE FORM FOR ANTIEPILEPTIC DRUGS | ALZA CORPORATION (US) | 1997-02-19 | — | — | EP | claimed |
| EP-0729748-A1 | PROCESS FOR PRODUCING STABLE MEDICINAL COMPOSITION, AND PHARMACEUTICAL PREPARATION | NIPPON SHINYAKU COMPANY, LIMITED (JP) | 1996-09-04 | — | — | EP | claimed |
| WO-1995029665-A1 | EFFECTIVE DOSAGE FORM FOR ANTIEPILEPTIC DRUGS | ALZA CORPORATION (US) | 1995-11-09 | — | — | WO | claimed |
| WO-1993008801-A1 | PREVENTION OF DRUG-INDUCED AGRANULOCYTOSIS WITH FREE RADICAL SCAVENGERS | THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 1993-05-13 | — | — | WO | claimed |
| US-5192550-A | Dosage form for treating central nervous system disorders | ALZA CORPORATION (US) | 1993-03-09 | — | — | US | claimed |
| US-4517309-A | Method for the treatment of calcifying pancreatitis | NODA AIJI (JP) | 1985-05-14 | — | — | US | claimed |
| US-4175119-A | Composition and method to prevent accidental and intentional overdosage with psychoactive drugs | PORTER GARRY L | 1979-11-20 | — | — | US | claimed |
| US-4160818-A | Fluorimetric immunoassay for diphenylhydantoin | TECHNICON INSTRUMENTS CORPORATION (US) | 1979-07-10 | — | — | US | claimed |