Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Proglumetacin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 known ✓ | P35354 | 17/20 | 0.49 |
| ▸ | PTGS1 known ✓ | P23219 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Proglumetacin SCHEMBL29384391 | 0.91 | PTGS2 (0.59) | PTGS2HTR1APKMPTGS1GLO1 | |
| Proglumetacin SCHEMBL27106 | 0.91 | PTGS2 (0.59) | PTGS2HTR1APKMPTGS1GLO1 | |
| Proglumetacin SCHEMBL1650599 | 0.89 | PTGS2 (0.56) | PTGS2HTR1APKMPTGS1GLO1 | |
| Proglumetacin SCHEMBL19642980 | 0.89 | PTGS2 (0.56) | PTGS2HTR1APKMPTGS1GLO1 | |
| Proglumetacin SCHEMBL99165 | 0.89 | PTGS2 (0.56) | PTGS2HTR1APKMPTGS1GLO1 | |
| Proglumetacin SCHEMBL2070226 | 0.88 | PTGS2 (0.55) | PTGS2PTGS1 | |
| Proglumetacin SCHEMBL28086382 | 0.88 | PTGS2 (0.55) | PTGS2PTGS1 | |
| SCHEMBL5077578 | 0.83 | PTGS2 (0.57) | PTGS2HTR1APKMPTGS1GLO1 | |
| Proglumetacin SCHEMBL4094289 | 0.82 | PTGS2 (0.52) | PTGS2 | |
| Proglumetacin SCHEMBL5482765 | 0.81 | PTGS2 (0.47) | PTGS2HTR1APKMPTGS1GLO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2699572-A1 | HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS | Origenis GmbH (DE) | 2014-02-26 | — | — | EP | disclosed |
| EP-2699579-A1 | PYRAZOLO [4, 3-D]PYRIMIDINES USEFUL AS KINASE INHIBITORS | Origenis GmbH (DE) | 2014-02-26 | — | — | EP | disclosed |
| WO-2012143143-A1 | HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS | ORIGENIS GMBH (DE) | 2012-10-26 | — | — | WO | disclosed |
| WO-2012143144-A1 | PYRAZOLO [4, 3-D] PYRIMIDINES USEFUL AS KINASE INHIBITORS | ORIGENIS GMBH (DE) | 2012-10-26 | — | — | WO | disclosed |