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Proglumetacin

Proglumetacin

SCHEMBL28086382

CCCN(CCC)C(=O)C(CCC(=O)OCCCN1CCN(CCOC(=O)Cc2c(C)n(C(=O)c3ccc(Cl)cc3)c3ccc(OC)cc23)CC1)NC(=O)c1ccccc1.COc1ccc2c(c1)c(CC(=O)NO)c(C)n2C(=O)c1ccc(Cl)cc1

nearest known ligand 0.55

Full drug profile on Sugi Atlas →

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
▸ PTGS2 P35354 16/20 0.55
▸ PTGS1 P23219 1/20 0.52
▸ BCL2L1 Q07817 2/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Proglumetacin SCHEMBL2070226 1.00 PTGS2 (0.55) PTGS2PTGS1BCL2L1
Proglumetacin SCHEMBL27106 0.97 PTGS2 (0.59) PTGS2PTGS1
Proglumetacin SCHEMBL29384391 0.97 PTGS2 (0.59) PTGS2PTGS1
Proglumetacin SCHEMBL99165 0.94 PTGS2 (0.56) PTGS2PTGS1
Proglumetacin SCHEMBL19642980 0.94 PTGS2 (0.56) PTGS2PTGS1
Proglumetacin SCHEMBL1650599 0.94 PTGS2 (0.56) PTGS2PTGS1
SCHEMBL5077578 0.88 PTGS2 (0.57) PTGS2PTGS1
Proglumetacin SCHEMBL4094289 0.88 PTGS2 (0.52) PTGS2
Proglumetacin SCHEMBL13724384 0.88 PTGS2 (0.49) PTGS2PTGS1
Proglumetacin SCHEMBL5482765 0.86 PTGS2 (0.47) PTGS2PTGS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-103717597-B Heterocyclic compounds as kinase inhibitors 原真股份有限公司 2017-07-04 — — CN disclosed
CN-103492389-B Pyrazolo [4,3-d] pyrimidine as inhibitors of kinases 原真股份有限公司 2016-09-14 — — CN disclosed