Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | JAK1 | P23458 | 1/20 | 0.45 |
| ▸ | TYK2 | P29597 | 1/20 | 0.45 |
| ▸ | JAK3 | P52333 | 1/20 | 0.45 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.44 |
| ▸ | HTR6 | P50406 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.42 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13728773 | 0.85 | P2RX3 (0.45) | SMN1; SMN2 | |
| SCHEMBL13728292 | 0.82 | HTR2C (0.43) | NR3C2CHEK2HTR6AURKARPS6KB1 | |
| SCHEMBL13728200 | 0.78 | MEN1 (0.46) | TDP1HTR6MEN1KMT2AAURKA | |
| SCHEMBL13726969 | 0.76 | MAOB (0.46) | NR3C2AURKARPS6KB1 | |
| SCHEMBL5252905 | 0.74 | NR3C2 (0.54) | NR3C2HTR6POLBAURKARPS6KB1 | |
| SCHEMBL6305112 | 0.74 | NNMT (0.39) | ADORA3 | |
| SCHEMBL21722444 | 0.74 | TDP1 (0.49) | TDP1NR3C2CHEK2MEN1KMT2A | |
| SCHEMBL30006783 | 0.74 | TDP1 (0.49) | TDP1NR3C2CHEK2POLBAURKA | |
| SCHEMBL1568380 | 0.74 | CHEK2 (0.49) | TDP1NR3C2CHEK2NPSR1PARP14 | |
| SCHEMBL13726397 | 0.73 | KCNA5 (0.43) | CHEK2KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012151567-A1 | PYRIMIDINONE COMPOUNDS AND METHODS FOR PREVENTING AND TREATING INFLUENZA | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) | 2012-11-08 | — | — | WO | disclosed |