Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.43 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.43 |
| ▸ | BRAF | P15056 | 2/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.41 |
| ▸ | TDO2 | P48775 | 2/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26317676 | 0.86 | PDE10A (0.43) | PDE10APDGFRBPDGFRABRAFCYP11B1 | |
| SCHEMBL30517018 | 0.79 | POLB (0.40) | PDE10ACYP11B1CYP11B2TDO2IDO1 | |
| SCHEMBL25840214 | 0.79 | POLB (0.40) | PDE10ACYP11B1CYP11B2TDO2IDO1 | |
| SCHEMBL27983652 | 0.79 | PDE10A (0.43) | PDE10ACYP11B1CYP11B2 | |
| SCHEMBL13729147 | 0.76 | PDE10A (0.38) | PDE10APDGFRBPDGFRATRPA1 | |
| SCHEMBL24773765 | 0.76 | ACHE (0.53) | PDGFRBPDGFRATRPA1 | |
| SCHEMBL1536378 | 0.73 | CYP11B1 (0.49) | PDE10ABRAFCYP11B1CYP11B2 | |
| SCHEMBL22559289 | 0.72 | LCK (0.50) | PDE10ACYP11B1CYP11B2 | |
| SCHEMBL20975068 | 0.72 | CYP11B2 (0.37) | BRAFCYP11B1CYP11B2TDO2IDO1 | |
| SCHEMBL30701983 | 0.72 | CYP11B2 (0.37) | BRAFCYP11B1CYP11B2TDO2IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2909205-A1 | HEPATITIS C VIRUS INHIBITORS | Bristol-Myers Squibb Company (US) | 2015-08-26 | — | — | EP | disclosed |
| WO-2014062196-A1 | HEPATITIS C VIRUS INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2014-04-24 | — | — | WO | disclosed |
| EP-2705049-A1 | HEPATITIS C VIRUS INHIBITORS | Bristol-Myers Squibb Company (US) | 2014-03-12 | — | — | EP | disclosed |
| WO-2012151195-A1 | HEPATITIS C VIRUS INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-11-08 | — | — | WO | disclosed |