Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 1/20 | 0.53 |
| ▸ | BTK | Q06187 | 1/20 | 0.53 |
| ▸ | PI4K2A | Q9BTU6 | 2/20 | 0.49 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.45 |
| ▸ | CCNC | P24863 | 3/20 | 0.44 |
| ▸ | CDK8 | P49336 | 3/20 | 0.44 |
| ▸ | CDK19 | Q9BWU1 | 2/20 | 0.43 |
| ▸ | MPO | P05164 | 3/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.40 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.40 |
| ▸ | BRAF | P15056 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13728578 | 0.78 | LCK (0.47) | LCKBTKPI4K2ARIPK2CCNC | |
| SCHEMBL21292970 | 0.74 | HPGD (0.39) | LCKJAK3ARHPGD | |
| SCHEMBL15288109 | 0.71 | LCK (0.60) | LCKBTKPI4K2ARIPK2CCNC | |
| SCHEMBL30369932 | 0.70 | LCK (0.56) | LCKBTKPI4K2ARIPK2CCNC | |
| SCHEMBL27682000 | 0.70 | LCK (0.56) | LCKBTKPI4K2ARIPK2CCNC | |
| SCHEMBL28136345 | 0.70 | LCK (0.56) | LCKBTKPI4K2ARIPK2CCNC | |
| SCHEMBL15288088 | 0.69 | BTK (1.00) | LCKBTKPI4K2ARIPK2CCNC | |
| SCHEMBL2745360 | 0.69 | DHFR (0.59) | LCKBTKPI4K2ACCNCCDK8 | |
| SCHEMBL29740960 | 0.68 | AR (0.56) | LCKBTKAR | |
| SCHEMBL15288512 | 0.68 | BTK (0.70) | LCKBTKPI4K2ARIPK2MPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012151567-A1 | PYRIMIDINONE COMPOUNDS AND METHODS FOR PREVENTING AND TREATING INFLUENZA | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) | 2012-11-08 | — | — | WO | disclosed |