SCHEMBL13728852

SCHEMBL13728852

Oc1nc(-c2ccccc2C(F)(F)F)nc(O)c1O

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 13/20 0.48
CYP2D6 P10635 10/20 0.48
CYP2C19 P33261 9/20 0.48
CLK4 Q9HAZ1 5/20 0.48
CYP2C9 P11712 3/20 0.48
RECQL P46063 1/20 0.48
CYP3A4 P08684 10/20 0.46
TSHR P16473 6/20 0.46
HSD17B10 Q99714 5/20 0.46
ALDH1A1 P00352 4/20 0.46
ALOX15 P16050 3/20 0.46
MAPK1 P28482 2/20 0.46
HIF1A Q16665 1/20 0.46
TDP1 Q9NUW8 1/20 0.46
MEN1 O00255 3/20 0.43
KMT2A Q03164 3/20 0.43
USP1 O94782 2/20 0.43
WDR48 Q8TAF3 2/20 0.43
HSD11B1 P28845 1/20 0.43
LMNA P02545 3/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13732093 0.78 SMN1; SMN2 (0.51) TSHRALDH1A1MEN1KMT2AKDM4E
SCHEMBL13824309 0.77 CNR2 (0.40) CYP1A2CYP2D6CYP2C19CLK4CYP2C9
SCHEMBL805589 0.74 HSD11B1 (0.51) CYP1A2CYP2D6CYP2C19CLK4CYP2C9
SCHEMBL805590 0.74 HSD11B1 (0.51) CYP1A2CYP2D6CYP2C19CLK4CYP2C9
SCHEMBL31138735 0.74 TRPA1 (0.39) CYP1A2CYP2D6CYP2C19CLK4CYP2C9
SCHEMBL31138561 0.74 CYP1A2 (0.39) CYP1A2CYP2D6CYP2C19CLK4CYP2C9
SCHEMBL23911666 0.74 AKR1B1 (0.46) CYP1A2CYP2D6CYP2C19CLK4CYP2C9
SCHEMBL5215493 0.74 CYP1A2 (0.61) CYP1A2CYP2D6CYP2C19CLK4CYP2C9
SCHEMBL7011881 0.72 CYP1A2 (0.60) CYP1A2CYP2D6CYP2C19CLK4CYP2C9
SCHEMBL29904766 0.72 CYP1A2 (0.60) CYP1A2CYP2D6CYP2C19CLK4CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012151567-A1 PYRIMIDINONE COMPOUNDS AND METHODS FOR PREVENTING AND TREATING INFLUENZA ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) 2012-11-08 WO disclosed