Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 2/20 | 0.40 |
| ▸ | ANPEP | P15144 | 1/20 | 0.38 |
| ▸ | S1PR4 | O95977 | 3/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.35 |
| ▸ | FPR1 | P21462 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13728858 | 0.85 | SMN1; SMN2 (0.41) | POLBALDH1A1CYP2C19MEN1KMT2A | |
| SCHEMBL15956851 | 0.79 | CYP2C9 (0.37) | CYP2C19CYP1A2CYP2C9SMN1; SMN2CYP3A4 | |
| SCHEMBL13731301 | 0.79 | NPC1 (0.46) | POLBALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL13505897 | 0.79 | POLB (0.46) | POLBALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL15771740 | 0.79 | ALDH1A1 (0.47) | ALDH1A1MEN1KMT2ASMN1; SMN2TP53 | |
| SCHEMBL13731431 | 0.78 | ALPL (0.44) | POLBALDH1A1KMT2ASMN1; SMN2TP53 | |
| SCHEMBL13730516 | 0.78 | NPC1 (0.32) | POLBCYP2C19CYP1A2CYP2C9SMN1; SMN2 | |
| SCHEMBL13731696 | 0.78 | RAB9A (0.46) | CYP2C19MEN1KMT2ACYP1A2CYP2C9 | |
| SCHEMBL13729899 | 0.78 | CCNA2 (0.50) | ATMLCKCYP2C19CYP1A2SMN1; SMN2 | |
| SCHEMBL13729355 | 0.76 | RAB9A (0.50) | POLBALDH1A1CYP2C19KMT2ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9340547-B2 | Pyrrolotriazinone derivatives as inhibitors P13K | ALMIRALL, S.A. (ES) | 2016-05-17 | — | — | US | disclosed |
| EP-2702061-B9 | PYRROLOTRIAZINONE DERIVATIVES AS PI3K INHIBITORS | ALMIRALL SA (ES) | 2016-02-24 | — | — | EP | disclosed |
| EP-2702061-B1 | PYRROLOTRIAZINONE DERIVATIVES AS PI3K INHIBITORS | ALMIRALL SA (ES) | 2015-07-29 | — | — | EP | disclosed |
| US-20150099752-A9 | PYRROLOTRIAZINONE DERIVATIVES AS PI3K INHIBITORS | ALMIRALL, SA (ES) | 2015-04-09 | — | — | US | disclosed |
| US-20140163033-A1 | PYRROLOTRIAZINONE DERIVATIVES AS P13K INHIBITORS | ALMIRALL, SA (ES) | 2014-06-12 | — | — | US | disclosed |
| EP-2702061-A1 | PYRROLOTRIAZINONE DERIVATIVES AS PI3K INHIBITORS | Almirall S.A. (ES) | 2014-03-05 | — | — | EP | disclosed |
| WO-2012146666-A1 | PYRROLOTRIAZINONE DERIVATIVES AS PI3K INHIBITORS | ALMIRALL, S.A. (ES) | 2012-11-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140163033-A1 | PYRROLOTRIAZINONE DERIVATIVES AS P13K INHIBITORS | PIP4K2B, PDPK1, PI4KA | POLB 589/4885ATM 451/4885ANPEP 3348/4885 |
| US-20150099752-A9 | PYRROLOTRIAZINONE DERIVATIVES AS PI3K INHIBITORS | PIK3CD, PIK3CA, PIK3CB | POLB 468/4885ATM 527/4885ANPEP 4055/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.