Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 1/20 | 0.35 |
| ▸ | TRPV4 | Q9HBA0 | 8/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.32 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.32 |
| ▸ | LOX | P28300 | 1/20 | 0.31 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.31 |
| ▸ | NAMPT | P43490 | 1/20 | 0.30 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13732234 | 0.83 | GBA1 (0.38) | GBA1TRPV4DPP4NR1H2NR1H3 | |
| SCHEMBL30807872 | 0.75 | GBA1 (0.41) | GBA1DPP4NR1H2NR1H3LOX | |
| SCHEMBL13730850 | 0.74 | LMNA (0.41) | GBA1NR1H2NR1H3LOXKAT6A | |
| SCHEMBL13731094 | 0.71 | LOX (0.39) | GBA1NR1H2NR1H3LOXKAT6A | |
| SCHEMBL13730423 | 0.71 | NAMPT (0.34) | GBA1NR1H2NR1H3LOXKAT6A | |
| SCHEMBL25405123 | 0.70 | EPAS1 (0.37) | GBA1NR1H2NR1H3LOXKAT6A | |
| SCHEMBL17530475 | 0.69 | LOX (0.35) | GBA1NR1H2NR1H3LOXEPAS1 | |
| SCHEMBL13731260 | 0.68 | CYP4F2 (0.37) | NR1H2NR1H3LOXKAT6AEPAS1 | |
| SCHEMBL13730672 | 0.68 | EPAS1 (0.38) | GBA1NR1H2NR1H3LOXKAT6A | |
| SCHEMBL13731602 | 0.68 | LOX (0.40) | GBA1NR1H2NR1H3LOXKAT6A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2699543-A1 | NOVEL MODULATORS OF CORTICAL DOPAMINERGIC- AND NMDA-RECEPTOR-MEDIATED GLUTAMATERGIC NEUROTRANSMISSION | Integrative Research Laboratories Sweden AB (SE) | 2014-02-26 | — | — | EP | claimed |
| WO-2012143337-A1 | NOVEL MODULATORS OF CORTICAL DOPAMINERGIC- AND NMDA-RECEPTOR-MEDIATED GLUTAMATERGIC NEUROTRANSMISSION | NEUROSEARCH A/S (DK) | 2012-10-26 | — | — | WO | claimed |
| EP-2699543-A1 | NOVEL MODULATORS OF CORTICAL DOPAMINERGIC- AND NMDA-RECEPTOR-MEDIATED GLUTAMATERGIC NEUROTRANSMISSION | Integrative Research Laboratories Sweden AB (SE) | 2014-02-26 | — | — | EP | disclosed |
| WO-2012143337-A1 | NOVEL MODULATORS OF CORTICAL DOPAMINERGIC- AND NMDA-RECEPTOR-MEDIATED GLUTAMATERGIC NEUROTRANSMISSION | NEUROSEARCH A/S (DK) | 2012-10-26 | — | — | WO | disclosed |