Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 13/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 8/20 | 0.47 |
| ▸ | PARP1 | P09874 | 1/20 | 0.45 |
| ▸ | KHK | P50053 | 1/20 | 0.44 |
| ▸ | CCR5 | P51681 | 1/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3407129 | 0.99 | OPRL1 (0.46) | OPRL1OPRM1PARP1KHKCCR5 | |
| SCHEMBL23719075 | 0.93 | OPRL1 (0.46) | OPRL1OPRM1OPRK1ALDH1A1 | |
| SCHEMBL23718993 | 0.86 | CCR5 (0.54) | OPRL1OPRM1CCR5OPRK1CNR2 | |
| SCHEMBL27835998 | 0.80 | KDM4E (0.48) | OPRL1OPRM1CCR5ALDH1A1 | |
| SCHEMBL23719083 | 0.80 | OPRL1 (0.41) | OPRL1OPRM1OPRK1 | |
| SCHEMBL27835999 | 0.79 | OPRL1 (0.49) | OPRL1OPRM1CCR5OPRK1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL23699334 | 0.79 | OPRL1 (0.41) | OPRL1OPRM1OPRK1 | |
| SCHEMBL28026560 | 0.76 | KMT2A (0.54) | OPRL1OPRM1ALDH1A1 | |
| SCHEMBL17439133 | 0.75 | OPRL1 (0.71) | OPRL1OPRM1CCR5OPRK1 | |
| SCHEMBL24324292 | 0.75 | KHK (0.61) | PARP1KHKALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9206156-B2 | Substituted indole derivatives | Grünenthal GmbH (DE) | 2015-12-08 | — | — | US | disclosed |
| US-9206156-B2 | Substituted indole derivatives | Grünenthal GmbH (DE) | 2015-12-08 | — | — | US | disclosed |
| US-20130116283-A1 | Substituted indole derivatives | Grünenthal GmbH (DE) | 2013-05-09 | — | — | US | disclosed |
| US-20130116283-A1 | Substituted indole derivatives | Grünenthal GmbH (DE) | 2013-05-09 | — | — | US | disclosed |
| US-20090215828-A1 | Substituted indole derivatives | GRUNENTHAL GMBH (DE) | 2009-08-27 | — | — | US | disclosed |
| US-20090215828-A1 | Substituted indole derivatives | GRUNENTHAL GMBH (DE) | 2009-08-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090215828-A1 | Substituted indole derivatives | IDO1, IDO2, TPH1 | OPRL1 25/4885OPRM1 30/4885PARP1 769/4885 |
| US-20130116283-A1 | Substituted indole derivatives | IDO1, IDO2, TPH1 | OPRL1 25/4885OPRM1 30/4885PARP1 769/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.