Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.49 |
| ▸ | OPRL1 | P41146 | 5/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27835998 | 0.89 | KDM4E (0.48) | KMT2AOPRM1OPRL1KDM4EALDH1A1 | |
| SCHEMBL23718993 | 0.84 | CCR5 (0.54) | KMT2AMEN1OPRM1OPRL1ALDH1A1 | |
| SCHEMBL27835999 | 0.83 | OPRL1 (0.49) | KMT2AOPRM1OPRL1KDM4EALDH1A1 | |
| SCHEMBL4276385 | 0.82 | OPRM1 (0.62) | OPRM1OPRL1LMNA | |
| SCHEMBL3404124 | 0.80 | KMT2A (0.56) | KMT2AMEN1OPRM1OPRL1KDM4E | |
| SCHEMBL3434218 | 0.80 | ALDH1A1 (0.52) | KMT2AMEN1OPRM1OPRL1KDM4E | |
| SCHEMBL3403507 | 0.79 | GABRA1 (0.44) | OPRM1OPRL1KDM4EALDH1A1HPGD | |
| SCHEMBL4109110 | 0.78 | GABRA1 (0.53) | OPRM1OPRL1HSD11B1 | |
| SCHEMBL3408116 | 0.78 | GABRA1 (0.43) | OPRM1OPRL1ALDH1A1HPGDHSD11B1 | |
| SCHEMBL3410714 | 0.77 | UTS2R (0.48) | KMT2AMEN1OPRM1OPRL1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102015683-B | The indole derivatives replaced | GRUNENTHAL GMBH (DE) | 2015-08-05 | — | — | CN | claimed |
| CN-102015683-B | The indole derivatives replaced | GRUNENTHAL GMBH (DE) | 2015-08-05 | — | — | CN | disclosed |