Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.41 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.36 |
| ▸ | NR3C2 | P08235 | 5/20 | 0.36 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.36 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | HTR6 | P50406 | 1/20 | 0.33 |
| ▸ | MELK | Q14680 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.33 |
| ▸ | FYN | P06241 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13734967 | 0.87 | HRH4 (0.53) | HRH4MAPKAPK2NR3C2DRD2HTR6 | |
| SCHEMBL13735487 | 0.83 | AR (0.49) | HRH4ARPTGS2NPC1ALDH1A1 | |
| SCHEMBL13734720 | 0.82 | HRH4 (0.39) | HRH4MAPKAPK2NR3C2MAPK9MAPK10 | |
| SCHEMBL13734775 | 0.79 | KDM4E (0.40) | DRD2NPC1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL13736485 | 0.78 | DGAT1 (0.56) | NR3C2DGAT1DRD2PTGS2NPC1 | |
| SCHEMBL13734946 | 0.74 | FYN (0.53) | HRH4MAPKAPK2DRD2HTR6MELK | |
| SCHEMBL13734515 | 0.72 | MELK (0.57) | HRH4MAPK9MAPK10DGAT1MELK | |
| SCHEMBL13734494 | 0.71 | NR3C2 (0.38) | HRH4NR3C2MAPK9MAPK10ALDH1A1 | |
| SCHEMBL13734733 | 0.70 | NPC1 (0.56) | MAPK9MAPK10DGAT1MELKPTGS2 | |
| SCHEMBL13736834 | 0.68 | HRH4 (0.42) | HRH4MELKNPC1ALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2699579-A1 | PYRAZOLO [4, 3-D]PYRIMIDINES USEFUL AS KINASE INHIBITORS | Origenis GmbH (DE) | 2014-02-26 | — | — | EP | disclosed |
| WO-2012143144-A1 | PYRAZOLO [4, 3-D] PYRIMIDINES USEFUL AS KINASE INHIBITORS | ORIGENIS GMBH (DE) | 2012-10-26 | — | — | WO | disclosed |