Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | NR3C2 | P08235 | 5/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
| ▸ | LGMN | Q99538 | 2/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.34 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.34 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | MTOR | P42345 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13735487 | 0.88 | AR (0.49) | HRH4ARALDH1A1MAPTPTGS2 | |
| SCHEMBL13734967 | 0.86 | HRH4 (0.53) | HRH4NR3C2ALDH1A1MAPTMAPKAPK2 | |
| SCHEMBL13734142 | 0.82 | HRH4 (0.41) | HRH4ARNR3C2ALDH1A1MAPK9 | |
| SCHEMBL13735901 | 0.77 | ALDH1A1 (0.43) | ALDH1A1MAPTLGMN | |
| SCHEMBL13734536 | 0.76 | DGAT1 (0.55) | NR3C2ALDH1A1MAPTPTGS2DGAT1 | |
| SCHEMBL13734494 | 0.75 | NR3C2 (0.38) | HRH4NR3C2ALDH1A1MAPTMAPK9 | |
| SCHEMBL13734946 | 0.73 | FYN (0.53) | HRH4ALDH1A1MAPTMAPKAPK2 | |
| SCHEMBL13734778 | 0.71 | CHKA (0.56) | NR3C2MAPK9MAPK10PTGS2DGAT1 | |
| SCHEMBL13734515 | 0.70 | MELK (0.57) | HRH4ALDH1A1MAPTMAPK9MAPK10 | |
| SCHEMBL13734685 | 0.70 | MAPK9 (0.54) | ARALDH1A1MAPTMAPK9MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2699579-A1 | PYRAZOLO [4, 3-D]PYRIMIDINES USEFUL AS KINASE INHIBITORS | Origenis GmbH (DE) | 2014-02-26 | — | — | EP | claimed |
| WO-2012143144-A1 | PYRAZOLO [4, 3-D] PYRIMIDINES USEFUL AS KINASE INHIBITORS | ORIGENIS GMBH (DE) | 2012-10-26 | — | — | WO | claimed |
| EP-2699579-A1 | PYRAZOLO [4, 3-D]PYRIMIDINES USEFUL AS KINASE INHIBITORS | Origenis GmbH (DE) | 2014-02-26 | — | — | EP | disclosed |
| WO-2012143144-A1 | PYRAZOLO [4, 3-D] PYRIMIDINES USEFUL AS KINASE INHIBITORS | ORIGENIS GMBH (DE) | 2012-10-26 | — | — | WO | disclosed |