Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 1/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.44 |
| ▸ | MTOR | P42345 | 1/20 | 0.44 |
| ▸ | PRKDC | P78527 | 3/20 | 0.43 |
| ▸ | GAK | O14976 | 1/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.39 |
| ▸ | EP300 | Q09472 | 1/20 | 0.38 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13734967 | 0.88 | HRH4 (0.53) | HRH4ALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL13734720 | 0.88 | HRH4 (0.39) | ARPTGS2PIK3CAPIK3CGMTOR | |
| SCHEMBL13734142 | 0.83 | HRH4 (0.41) | ARPTGS2HRH4ALDH1A1SMN1; SMN2 | |
| SCHEMBL13734685 | 0.82 | MAPK9 (0.54) | ARPTGS2PIK3CAALDH1A1SMN1; SMN2 | |
| SCHEMBL13736967 | 0.80 | PTGS2 (0.60) | ARPTGS2PRKDCALDH1A1SMN1; SMN2 | |
| SCHEMBL31025635 | 0.79 | AR (0.55) | ARPIK3CAPIK3CGMTORPRKDC | |
| SCHEMBL13733749 | 0.77 | PTGS2 (0.52) | ARPTGS2ALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL13734652 | 0.76 | NPC1 (0.56) | PTGS2PIK3CAPIK3CGMTORPRKDC | |
| SCHEMBL13734494 | 0.76 | NR3C2 (0.38) | HRH4ALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL13735472 | 0.74 | DGAT1 (0.57) | PTGS2PIK3CAPRKDCALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2699579-A1 | PYRAZOLO [4, 3-D]PYRIMIDINES USEFUL AS KINASE INHIBITORS | Origenis GmbH (DE) | 2014-02-26 | — | — | EP | claimed |
| WO-2012143144-A1 | PYRAZOLO [4, 3-D] PYRIMIDINES USEFUL AS KINASE INHIBITORS | ORIGENIS GMBH (DE) | 2012-10-26 | — | — | WO | claimed |
| EP-2699579-A1 | PYRAZOLO [4, 3-D]PYRIMIDINES USEFUL AS KINASE INHIBITORS | Origenis GmbH (DE) | 2014-02-26 | — | — | EP | disclosed |
| WO-2012143144-A1 | PYRAZOLO [4, 3-D] PYRIMIDINES USEFUL AS KINASE INHIBITORS | ORIGENIS GMBH (DE) | 2012-10-26 | — | — | WO | disclosed |