Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.41 |
| ▸ | CNR1 | P21554 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 2/20 | 0.39 |
| ▸ | EGFR | P00533 | 2/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.39 |
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13734748 | 1.00 | CYP1B1 (0.41) | CYP1B1CNR1MAPTL3MBTL1ALDH1A1 | |
| SCHEMBL13736516 | 0.88 | ALDH1A1 (0.47) | CYP1B1MAPTALDH1A1GRIN1GRIN2B | |
| SCHEMBL13734851 | 0.88 | ALDH1A1 (0.47) | CYP1B1MAPTALDH1A1GRIN1GRIN2B | |
| SCHEMBL15497447 | 0.81 | GRIN1 (0.44) | CYP1B1MAPTALDH1A1GRIN1GRIN2B | |
| SCHEMBL13736472 | 0.81 | TRPA1 (0.54) | CYP1B1MAPTALDH1A1LMNAMAOB | |
| SCHEMBL13736125 | 0.81 | TRPA1 (0.54) | CYP1B1MAPTALDH1A1LMNAMAOB | |
| SCHEMBL13735449 | 0.78 | CYP1B1 (0.49) | CYP1B1MAPTALDH1A1LMNANPSR1 | |
| SCHEMBL13735453 | 0.78 | CYP1B1 (0.49) | CYP1B1MAPTALDH1A1LMNANPSR1 | |
| SCHEMBL13734790 | 0.76 | CYP1A1 (0.45) | CYP1B1MAOBCYP1A1NFE2L2 | |
| SCHEMBL13734791 | 0.76 | CYP1A1 (0.45) | CYP1B1MAOBCYP1A1NFE2L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9334253-B2 | Direct trifluoromethylations using trifluoromethane | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2016-05-10 | — | — | US | claimed |
| US-20140066640-A1 | DIRECT TRIFLUOROMETHYLATIONS USING TRIFLUOROMETHANE | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2014-03-06 | — | — | US | claimed |
| WO-2012148772-A1 | DIRECT TRIFLUOROMETHYLATIONS USING TRIFLUOROMETHANE | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2012-11-01 | — | — | WO | claimed |
| EP-2712367-B1 | DIRECT TRIFLUOROMETHYLATIONS USING TRIFLUOROMETHANE | UNIV SOUTHERN CALIFORNIA (US) | 2018-09-26 | — | — | EP | disclosed |
| US-9334253-B2 | Direct trifluoromethylations using trifluoromethane | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2016-05-10 | — | — | US | disclosed |
| US-9334253-B2 | Direct trifluoromethylations using trifluoromethane | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2016-05-10 | — | — | US | disclosed |
| US-9334253-B2 | Direct trifluoromethylations using trifluoromethane | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2016-05-10 | — | — | US | disclosed |
| US-20140066640-A1 | DIRECT TRIFLUOROMETHYLATIONS USING TRIFLUOROMETHANE | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2014-03-06 | — | — | US | disclosed |
| US-20140066640-A1 | DIRECT TRIFLUOROMETHYLATIONS USING TRIFLUOROMETHANE | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2014-03-06 | — | — | US | disclosed |
| US-20140066640-A1 | DIRECT TRIFLUOROMETHYLATIONS USING TRIFLUOROMETHANE | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2014-03-06 | — | — | US | disclosed |
| WO-2012148772-A1 | DIRECT TRIFLUOROMETHYLATIONS USING TRIFLUOROMETHANE | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2012-11-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140066640-A1 | DIRECT TRIFLUOROMETHYLATIONS USING TRIFLUOROMETHANE | TST, FLI1, CYP2F1 | CYP1B1 1586/4885CNR1 4425/4885MAPT 3128/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.