Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | IGF1R | P08069 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13735480 | 0.77 | GAA (0.36) | DRD4GAASMN1; SMN2MAPK14 | |
| SCHEMBL13737236 | 0.71 | KDM5A (0.44) | DRD4IGF1R | |
| SCHEMBL13734527 | 0.69 | MEN1 (0.50) | GAASMN1; SMN2IGF1R | |
| SCHEMBL17001804 | 0.69 | GAA (0.46) | DRD4GAASMN1; SMN2 | |
| SCHEMBL13735207 | 0.69 | GAA (0.44) | GAASMN1; SMN2 | |
| SCHEMBL13735126 | 0.69 | DRD4 (0.43) | DRD4GAASMN1; SMN2MAPK14 | |
| SCHEMBL17001818 | 0.68 | DRD4 (0.55) | DRD4GAASMN1; SMN2MAPK14IGF1R | |
| SCHEMBL13734629 | 0.68 | ROCK2 (0.45) | — | |
| SCHEMBL13734830 | 0.68 | NT5E (0.45) | — | |
| SCHEMBL15431898 | 0.68 | HSD11B1 (0.47) | DRD4GAASMN1; SMN2MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2699579-A1 | PYRAZOLO [4, 3-D]PYRIMIDINES USEFUL AS KINASE INHIBITORS | Origenis GmbH (DE) | 2014-02-26 | — | — | EP | claimed |
| WO-2012143144-A1 | PYRAZOLO [4, 3-D] PYRIMIDINES USEFUL AS KINASE INHIBITORS | ORIGENIS GMBH (DE) | 2012-10-26 | — | — | WO | claimed |
| EP-2699579-A1 | PYRAZOLO [4, 3-D]PYRIMIDINES USEFUL AS KINASE INHIBITORS | Origenis GmbH (DE) | 2014-02-26 | — | — | EP | disclosed |
| WO-2012143144-A1 | PYRAZOLO [4, 3-D] PYRIMIDINES USEFUL AS KINASE INHIBITORS | ORIGENIS GMBH (DE) | 2012-10-26 | — | — | WO | disclosed |