Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN22 | Q9Y2R2 | 20/20 | 1.00 |
| ▸ | PTPN11 | Q06124 | 11/20 | 1.00 |
| ▸ | PTPN6 | P29350 | 10/20 | 1.00 |
| ▸ | PTPRC | P08575 | 10/20 | 1.00 |
| ▸ | PTPN9 | P43378 | 10/20 | 1.00 |
| ▸ | PTPN2 | P17706 | 9/20 | 1.00 |
| ▸ | PTPN1 | P18031 | 9/20 | 1.00 |
| ▸ | DUSP3 | P51452 | 9/20 | 1.00 |
| ▸ | PTPRG | P23470 | 3/20 | 1.00 |
| ▸ | ACP1 | P24666 | 3/20 | 1.00 |
| ▸ | PTPN7 | P35236 | 3/20 | 1.00 |
| ▸ | PTPN13 | Q12923 | 3/20 | 1.00 |
| ▸ | DUSP22 | Q9NRW4 | 3/20 | 1.00 |
| ▸ | CDC14A | Q9UNH5 | 3/20 | 1.00 |
| ▸ | EPM2A | O95278 | 2/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15829181 | 0.87 | PTPN22 (1.00) | PTPN22PTPN11PTPN6PTPRCPTPN9 | |
| SCHEMBL15829159 | 0.85 | PTPN22 (0.83) | PTPN22PTPN11PTPN6PTPRCPTPN9 | |
| SCHEMBL13734961 | 0.82 | PTPN22 (1.00) | PTPN22PTPN11PTPN6PTPRCPTPN9 | |
| SCHEMBL13737097 | 0.81 | PTPN22 (1.00) | PTPN22PTPN11PTPN6PTPRCPTPN9 | |
| SCHEMBL15829183 | 0.79 | PTPN22 (0.82) | PTPN22PTPN11PTPN6PTPRCPTPN9 | |
| SCHEMBL15829160 | 0.79 | PTPN22 (0.88) | PTPN22PTPN11PTPN6PTPRCPTPN9 | |
| SCHEMBL15829185 | 0.79 | PTPN22 (1.00) | PTPN22PTPN11PTPN6PTPRCPTPN9 | |
| SCHEMBL15829166 | 0.78 | PTPN22 (0.78) | PTPN22PTPN11PTPN6PTPRCPTPN9 | |
| SCHEMBL18231232 | 0.78 | PTPN22 (0.80) | PTPN22PTPN11PTPN6PTPRCPTPN9 | |
| SCHEMBL15829174 | 0.77 | PTPN22 (1.00) | PTPN22PTPN11PTPN6PTPRCPTPN9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103561573-A | Tyrosine phosphatases and their use in modulating the activity of enzymes involved in the pathology of Mycobacterium tuberculosis | UNIV INDIANA RES & TECH CORP | 2014-02-05 | — | — | CN | claimed |
| WO-2012149049-A1 | TYROSINE PHOSPHATASE INHIBITORS AND USES THEREOF TO MODULATE THE ACTIVITY OF ENZYMES INVOLVED IN THE PATHOLOGY OF MYCOBACTERIUM TUBERCULOSIS | INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) | 2012-11-01 | — | — | WO | claimed |
| US-20230192904-A1 | BIFUNCTIONAL CHIMERIC MOLECULES FOR LABELING OF KINASES WITH TARGET BINDING MOIETIES AND METHODS OF USE THEREOF | THE BROAD INSTITUTE, INC. | 2023-06-22 | — | — | US | disclosed |
| WO-2023092094-A2 | BIFUNCTIONAL CHIMERIC MOLECULES FOR LABELING OF KINASES WITH TARGET BINDING MOIETIES AND METHODS OF USE THEREOF | THE BROAD INSTITUTE, INC. (US) | 2023-05-25 | — | — | WO | disclosed |
| US-20180170862-A1 | PROTEIN TYROSINE PHOSPHATASES OR SHP2 INHIBITORS AND USES THEREOF | INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION | 2018-06-21 | — | — | US | disclosed |
| US-20180170862-A1 | PROTEIN TYROSINE PHOSPHATASES OR SHP2 INHIBITORS AND USES THEREOF | INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION | 2018-06-21 | — | — | US | disclosed |
| US-20180170861-A1 | SMALL MOLECULE INHIBITORS OF PROTEIN TYROSINE PHOSPHATASES AND USED THEREOF | INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION | 2018-06-21 | — | — | US | disclosed |
| US-20180170861-A1 | SMALL MOLECULE INHIBITORS OF PROTEIN TYROSINE PHOSPHATASES AND USED THEREOF | INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION | 2018-06-21 | — | — | US | disclosed |
| US-9493436-B2 | Tyrosine phosphatase inhibitors and uses thereof to modulate the activity of enzymes involved in the pathology of Mycobacterium tuberculosis | INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) | 2016-11-15 | — | — | US | disclosed |
| US-9493436-B2 | Tyrosine phosphatase inhibitors and uses thereof to modulate the activity of enzymes involved in the pathology of Mycobacterium tuberculosis | INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) | 2016-11-15 | — | — | US | disclosed |
| US-9493436-B2 | Tyrosine phosphatase inhibitors and uses thereof to modulate the activity of enzymes involved in the pathology of Mycobacterium tuberculosis | INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) | 2016-11-15 | — | — | US | disclosed |
| US-20140179735-A1 | TYROSINE PHOSPHATASE INHIBITORS AND USES THEREOF TO MODULATE THE ACTIVITY OF ENZYMESp INVOLVED IN THE PATHOLOGY OF MYCOBACTERIUM TUBERCULOSIS | INDIANA UNIVERSITY RESEARCH & TECHNOLOGY CORPORATION | 2014-06-26 | — | — | US | disclosed |
| US-20140179735-A1 | TYROSINE PHOSPHATASE INHIBITORS AND USES THEREOF TO MODULATE THE ACTIVITY OF ENZYMESp INVOLVED IN THE PATHOLOGY OF MYCOBACTERIUM TUBERCULOSIS | INDIANA UNIVERSITY RESEARCH & TECHNOLOGY CORPORATION | 2014-06-26 | — | — | US | disclosed |
| CN-103561573-A | Tyrosine phosphatases and their use in modulating the activity of enzymes involved in the pathology of Mycobacterium tuberculosis | UNIV INDIANA RES & TECH CORP | 2014-02-05 | — | — | CN | disclosed |
| WO-2012149049-A1 | TYROSINE PHOSPHATASE INHIBITORS AND USES THEREOF TO MODULATE THE ACTIVITY OF ENZYMES INVOLVED IN THE PATHOLOGY OF MYCOBACTERIUM TUBERCULOSIS | INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) | 2012-11-01 | — | — | WO | disclosed |
| WO-2012149048-A1 | TYROSINE PHOSPHATASE INHIBITORS AND USES THEREOF TO MODULATE THE ACTIVITY OF LYP | INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) | 2012-11-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180170861-A1 | SMALL MOLECULE INHIBITORS OF PROTEIN TYROSINE PHOSPHATASES AND USED THEREOF | PTPA, EPM2A, PTPRA | PTPN22 24/4885PTPN11 60/4885PTPN6 28/4885 |
| US-20140179735-A1 | TYROSINE PHOSPHATASE INHIBITORS AND USES THEREOF TO MODULATE THE ACTIVITY OF ENZYMESp INVOLVED IN THE PATHOLOGY OF MYCOBACTERIUM TUBERCULOSIS | PPP3CB, PPP4C, PTPRB | PTPN22 69/4885PTPN11 142/4885PTPN6 84/4885 |
| US-20180170862-A1 | PROTEIN TYROSINE PHOSPHATASES OR SHP2 INHIBITORS AND USES THEREOF | PTPA, PTPRA, PTPRCAP | PTPN22 13/4885PTPN11 48/4885PTPN6 23/4885 |
| US-20230192904-A1 | BIFUNCTIONAL CHIMERIC MOLECULES FOR LABELING OF KINASES WITH TARGET BINDING MOIETIES AND METHODS OF USE THEREOF | ERBB2, ACP1, TK1 | PTPN22 1032/4885PTPN11 1753/4885PTPN6 1097/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.