Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 5/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | FYN | P06241 | 2/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.39 |
| ▸ | MELK | Q14680 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.37 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13734373 | 0.89 | PTGS2 (0.43) | NPC1SMN1; SMN2RAB9AALDH1A1TDP1 | |
| SCHEMBL13734733 | 0.82 | NPC1 (0.56) | MAP4K1NPC1SMN1; SMN2RAB9AALDH1A1 | |
| SCHEMBL13736077 | 0.82 | PIK3CD (0.53) | MAP4K1NPC1SMN1; SMN2RAB9AALDH1A1 | |
| SCHEMBL13733687 | 0.81 | MAP4K1 (0.42) | MAP4K1NPC1SMN1; SMN2RAB9AALDH1A1 | |
| SCHEMBL13733761 | 0.81 | JAK2 (0.54) | NPC1SMN1; SMN2RAB9AALDH1A1DGAT1 | |
| SCHEMBL13735060 | 0.80 | ALDH1A1 (0.47) | MAP4K1ALDH1A1FYNMELKMEN1 | |
| SCHEMBL28086120 | 0.78 | FYN (0.40) | MAP4K1ALDH1A1FYNMELKGAA | |
| SCHEMBL13737467 | 0.77 | NR3C2 (0.39) | SMN1; SMN2ALDH1A1GAAMAPK8MAPK9 | |
| SCHEMBL13734515 | 0.77 | MELK (0.57) | MAP4K1NPC1SMN1; SMN2RAB9AALDH1A1 | |
| SCHEMBL27932777 | 0.75 | PTGS2 (0.38) | NPC1RAB9AALDH1A1TDP1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2699579-A1 | PYRAZOLO [4, 3-D]PYRIMIDINES USEFUL AS KINASE INHIBITORS | Origenis GmbH (DE) | 2014-02-26 | — | — | EP | disclosed |
| WO-2012143144-A1 | PYRAZOLO [4, 3-D] PYRIMIDINES USEFUL AS KINASE INHIBITORS | ORIGENIS GMBH (DE) | 2012-10-26 | — | — | WO | disclosed |