Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 3/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.38 |
| ▸ | MELK | Q14680 | 1/20 | 0.38 |
| ▸ | HTR3A | P46098 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 5/20 | 0.37 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 4/20 | 0.36 |
| ▸ | PTK2 | Q05397 | 4/20 | 0.36 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.35 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13735233 | 0.78 | MAP4K1 (0.42) | FYNADRA2CALDH1A1KDM4EGAA | |
| SCHEMBL18656564 | 0.75 | ADRA2C (0.61) | ADRA2CALDH1A1KDM4EGAAMAPT | |
| SCHEMBL18656562 | 0.71 | MAPT (0.59) | ADRA2CALDH1A1KDM4EGAAMAPT | |
| SCHEMBL13734373 | 0.67 | PTGS2 (0.43) | FYNALDH1A1KDM4EMAPTKMT2A | |
| SCHEMBL28086177 | 0.66 | SIGMAR1 (0.50) | ADRA2CALDH1A1KDM4EMAPT | |
| SCHEMBL30108226 | 0.65 | MELK (0.60) | ADRA2CALDH1A1KDM4EGAAMAPT | |
| SCHEMBL24061151 | 0.64 | MAPKAPK2 (0.58) | ADRA2CALDH1A1KDM4EGAAMAPT | |
| SCHEMBL28845811 | 0.62 | ADRA2C (0.70) | FYNADRA2CALDH1A1KDM4EGAA | |
| SCHEMBL18642123 | 0.62 | HTR7 (0.57) | ALDH1A1MAPTHTR3A | |
| SCHEMBL18656551 | 0.62 | ADRA2C (0.42) | ADRA2CALDH1A1MAPTHTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103492389-B | Pyrazolo [4,3-d] pyrimidine as inhibitors of kinases | 原真股份有限公司 | 2016-09-14 | — | — | CN | disclosed |