Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | PPARG | P37231 | 1/20 | 0.48 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.47 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.46 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.46 |
| ▸ | STK4 | Q13043 | 3/20 | 0.46 |
| ▸ | STK3 | Q13188 | 3/20 | 0.46 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13735481 | 0.84 | KDM5A (0.47) | MAPTALDH1A1PTGS2NR3C2STK4 | |
| SCHEMBL13736967 | 0.83 | PTGS2 (0.60) | MAPTALDH1A1PTGS2NPC1RAB9A | |
| SCHEMBL13736564 | 0.81 | CNR2 (0.54) | CNR2MAPTALDH1A1PTGS2NPC1 | |
| SCHEMBL13734373 | 0.81 | PTGS2 (0.43) | CNR2MAPTALDH1A1PTGS2NR3C2 | |
| SCHEMBL13736077 | 0.81 | PIK3CD (0.53) | ALDH1A1PTGS2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL13736618 | 0.81 | LRRK2 (0.47) | ALDH1A1PTGS2LRRK2SMN1; SMN2PLK4 | |
| SCHEMBL13734495 | 0.81 | LRRK2 (0.48) | ALDH1A1PTGS2LRRK2SMN1; SMN2CYP1A2 | |
| SCHEMBL13737299 | 0.81 | CYP1A2 (0.51) | ALDH1A1PTGS2NR3C2STK4STK3 | |
| SCHEMBL27948417 | 0.80 | RPS6KA3 (0.47) | ALDH1A1PTGS2NR3C2SMN1; SMN2 | |
| SCHEMBL13734827 | 0.79 | JAK2 (0.56) | PTGS2AKR1C3PKMTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2699579-A1 | PYRAZOLO [4, 3-D]PYRIMIDINES USEFUL AS KINASE INHIBITORS | Origenis GmbH (DE) | 2014-02-26 | — | — | EP | claimed |
| WO-2012143144-A1 | PYRAZOLO [4, 3-D] PYRIMIDINES USEFUL AS KINASE INHIBITORS | ORIGENIS GMBH (DE) | 2012-10-26 | — | — | WO | claimed |