Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 3/20 | 0.51 |
| ▸ | TSHR | P16473 | 3/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.49 |
| ▸ | GSK3B | P49841 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.49 |
| ▸ | PRKDC | P78527 | 1/20 | 0.49 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13733761 | 0.89 | JAK2 (0.54) | CYP1A2TSHRCYP3A4MAPK1CYP2C19 | |
| SCHEMBL13734710 | 0.85 | DYRK1A (0.55) | CYP1A2TSHRCYP3A4MAPK1CYP2C19 | |
| SCHEMBL13735472 | 0.85 | DGAT1 (0.57) | L3MBTL1PTGS2GSK3BMEN1KMT2A | |
| SCHEMBL13735805 | 0.81 | CFTR (0.54) | CYP1A2TSHRCYP3A4CYP2C19CYP2C9 | |
| SCHEMBL13735826 | 0.81 | CNR2 (0.51) | CYP1A2TSHRMAPK1CYP2C19HSD17B10 | |
| SCHEMBL13735481 | 0.81 | KDM5A (0.47) | MAPK1HSD17B10L3MBTL1PTGS2ALDH1A1 | |
| SCHEMBL13736618 | 0.81 | LRRK2 (0.47) | PTGS2ALDH1A1DGAT1LRRK2 | |
| SCHEMBL13736077 | 0.81 | PIK3CD (0.53) | PTGS2ALDH1A1NPC1RAB9A | |
| SCHEMBL13736967 | 0.80 | PTGS2 (0.60) | CYP1A2TSHRMAPK1HSD17B10L3MBTL1 | |
| SCHEMBL13734737 | 0.79 | CD274 (0.48) | TSHRCYP2C19HSD17B10ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103492389-B | Pyrazolo [4,3-d] pyrimidine as inhibitors of kinases | 原真股份有限公司 | 2016-09-14 | — | — | CN | claimed |
| EP-2699579-A1 | PYRAZOLO [4, 3-D]PYRIMIDINES USEFUL AS KINASE INHIBITORS | Origenis GmbH (DE) | 2014-02-26 | — | — | EP | claimed |
| WO-2012143144-A1 | PYRAZOLO [4, 3-D] PYRIMIDINES USEFUL AS KINASE INHIBITORS | ORIGENIS GMBH (DE) | 2012-10-26 | — | — | WO | claimed |
| CN-103492389-B | Pyrazolo [4,3-d] pyrimidine as inhibitors of kinases | 原真股份有限公司 | 2016-09-14 | — | — | CN | disclosed |