Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.43 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.41 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.41 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.38 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.37 |
| ▸ | FYN | P06241 | 1/20 | 0.37 |
| ▸ | CSF1R | P07333 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13733687 | 0.89 | MAP4K1 (0.42) | LRRK2PIK3CDALDH1A1SMN1; SMN2MAPK8 | |
| SCHEMBL13735826 | 0.81 | CNR2 (0.51) | LRRK2PTGS2ALDH1A1SMN1; SMN2DGAT1 | |
| SCHEMBL13735481 | 0.81 | KDM5A (0.47) | LRRK2PTGS2PIK3CDALDH1A1SMN1; SMN2 | |
| SCHEMBL13736077 | 0.81 | PIK3CD (0.53) | PTGS2PIK3CDALDH1A1SMN1; SMN2PDE7A | |
| SCHEMBL13737299 | 0.81 | CYP1A2 (0.51) | LRRK2PTGS2ALDH1A1DGAT1 | |
| SCHEMBL13736967 | 0.80 | PTGS2 (0.60) | PTGS2ALDH1A1SMN1; SMN2ARMAPK9 | |
| SCHEMBL13734827 | 0.79 | JAK2 (0.56) | PTGS2PTGS1 | |
| SCHEMBL13734495 | 0.78 | LRRK2 (0.48) | LRRK2PTGS2ALDH1A1SMN1; SMN2MAPK10 | |
| SCHEMBL13734373 | 0.78 | PTGS2 (0.43) | PTGS2PIK3CDALDH1A1SMN1; SMN2AR | |
| SCHEMBL13736564 | 0.78 | CNR2 (0.54) | PTGS2ALDH1A1SMN1; SMN2AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2699579-A1 | PYRAZOLO [4, 3-D]PYRIMIDINES USEFUL AS KINASE INHIBITORS | Origenis GmbH (DE) | 2014-02-26 | — | — | EP | claimed |
| WO-2012143144-A1 | PYRAZOLO [4, 3-D] PYRIMIDINES USEFUL AS KINASE INHIBITORS | ORIGENIS GMBH (DE) | 2012-10-26 | — | — | WO | claimed |
| EP-2699579-A1 | PYRAZOLO [4, 3-D]PYRIMIDINES USEFUL AS KINASE INHIBITORS | Origenis GmbH (DE) | 2014-02-26 | — | — | EP | disclosed |
| WO-2012143144-A1 | PYRAZOLO [4, 3-D] PYRIMIDINES USEFUL AS KINASE INHIBITORS | ORIGENIS GMBH (DE) | 2012-10-26 | — | — | WO | disclosed |